Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions

被引：14
|
作者：
Sletmoen, Marit [1 ]
Gerken, Thomas A. [2 ,3 ]
Stokke, Bjorn T. [4 ]
Burchell, Joy [5 ]
Brewer, C. Fred [6 ,7 ]
机构：
[1] NTNU Norwegian Univ Sci & Technol, Dept Biotechnol & Food Sci, NO-7491 Trondheim, Norway
[2] Case Western Reserve Univ, WA Bernbaum Ctr Cyst Fibrosis Res, Dept Pediat, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, WA Bernbaum Ctr Cyst Fibrosis Res, Dept Biochem, Cleveland, OH 44106 USA
[4] NTNU Norwegian Univ Sci & Technol, Biophys & Med Technol, NO-7491 Trondheim, Norway
[5] Kings Coll London, Breast Canc Biol, Guys Hosp, London SE1 9RT, England
[6] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
[7] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA
来源：
GLYCOBIOLOGY | 2018年 / 28卷 / 07期
基金：
美国国家卫生研究院;
关键词：
carbohydrate tumor antigens; carbohydrate-carbohydrate interactions; mechanism of action; Neu5Gc-GM3; optical tweezers; Tn and STn cancer antigens; DYNAMIC FORCE SPECTROSCOPY; GROWTH-FACTOR RECEPTOR; SINGLE-MOLECULE; CANCER ANTIGENS; EXPRESSION; CELLS; MUCINS; GM3; GLYCOSYLATION; GANGLIOSIDE;
D O I：
10.1093/glycob/cwy032
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAc alpha 1-Ser/Thr) and STn (Neu5Ac alpha 2,6GalNAc alpha 1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate-carbohydrate interactions, CCIs) of Tn (Tn-Tn) and STn (STn-STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, which may participate in oncogenesis.
引用
收藏
页码：437 / 442
页数：6
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