Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions

被引：14

作者：

Sletmoen, Marit ^{[1
]}

Gerken, Thomas A. ^{[2
,3
]}

Stokke, Bjorn T. ^{[4
]}

Burchell, Joy ^{[5
]}

Brewer, C. Fred ^{[6
,7
]}

机构：

[1] NTNU Norwegian Univ Sci & Technol, Dept Biotechnol & Food Sci, NO-7491 Trondheim, Norway

[2] Case Western Reserve Univ, WA Bernbaum Ctr Cyst Fibrosis Res, Dept Pediat, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, WA Bernbaum Ctr Cyst Fibrosis Res, Dept Biochem, Cleveland, OH 44106 USA

[4] NTNU Norwegian Univ Sci & Technol, Biophys & Med Technol, NO-7491 Trondheim, Norway

[5] Kings Coll London, Breast Canc Biol, Guys Hosp, London SE1 9RT, England

[6] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

[7] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

来源：

GLYCOBIOLOGY | 2018年 / 28卷 / 07期

基金：

美国国家卫生研究院;

关键词：

carbohydrate tumor antigens; carbohydrate-carbohydrate interactions; mechanism of action; Neu5Gc-GM3; optical tweezers; Tn and STn cancer antigens; DYNAMIC FORCE SPECTROSCOPY; GROWTH-FACTOR RECEPTOR; SINGLE-MOLECULE; CANCER ANTIGENS; EXPRESSION; CELLS; MUCINS; GM3; GLYCOSYLATION; GANGLIOSIDE;

D O I：

10.1093/glycob/cwy032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAc alpha 1-Ser/Thr) and STn (Neu5Ac alpha 2,6GalNAc alpha 1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate-carbohydrate interactions, CCIs) of Tn (Tn-Tn) and STn (STn-STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, which may participate in oncogenesis.

引用

页码：437 / 442

页数：6

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