Enterocolitis due to immune checkpoint inhibitors: a systematic review

被引：211

作者：

Soularue, Emilie ^{[1
,2
]}

Lepage, Patricia ^{[3
]}

Colombel, Jean Frederic ^{[4
]}

Coutzac, Clelia ^{[5
,6
,7
]}

Faleck, David ^{[4
]}

Marthey, Lysiane ^{[1
]}

Collins, Michael ^{[1
,2
]}

Chaput, Nathalie ^{[5
,6
,7
,8
]}

Robert, Caroline ^{[2
,9
]}

Carbonnel, Franck ^{[1
,2
]}

机构：

[1] Kremlin Bicetre Hosp, AP HP, Dept Gastroenterol, Le Kremlin Bicetre, France

[2] Univ Paris Saclay, Fac Med, Le Kremlin Bicetre, France

[3] Univ Paris Saclay, AgroParisTech, INRA, Micalis Inst, Jouy En Josas, France

[4] Icahn Sch Med Mt Sinai, Helmsley Inflammatory Bowel Dis Ctr, New York, NY 10029 USA

[5] Lab Immunomonitoring Oncol, Villejuif, France

[6] CNRS, UMS 3655, Villejuif, France

[7] INSERM, US23, Villejuif, France

[8] Univ Paris Saclay, Fac Pharm, Chatenay Malabry, France

[9] Dermatol Unit, Dept Med, Villejuif, France

来源：

GUT | 2018年 / 67卷 / 11期

关键词：

IPILIMUMAB-INDUCED COLITIS; METASTATIC MELANOMA PATIENTS; INFLAMMATORY-BOWEL-DISEASE; ADVERSE EVENTS; COMBINED NIVOLUMAB; DOUBLE-BLIND; OPEN-LABEL; ENTERIC NEUROPATHY; 2ND LIGAND; STAGE-III;

D O I：

10.1136/gutjnl-2018-316948

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) and programmed death-1 (PD-1)/ ligand are increasingly used to treat several types of cancer. These drugs enhance antitumour T-cell activity and therefore induce immunerelated adverse effects (irAE), of which gastrointestinal (GI) irAE are among the most frequent and severe. This systematic literature review summarises the clinical manifestations, management and pathophysiology of GI irAE due to immune checkpoint inhibitors. GI irAE induced by anti-CTLA-4 are frequent, potentially severe and resemble IBD, whereas those induced by PD-1 blockade seem to be less frequent and clinically more diverse. Baseline symbiotic gut microbiota is associated with an enhanced antitumour response to immune checkpoint inhibitors and an increased susceptibility to developing enterocolitis, in patients treated with anti-CTLA-4. These findings open new perspectives for possible manipulation of the gut microbiota in order to better identify responders to immune checkpoint inhibitors and to increase their efficacy and safety.

引用

页码：2056 / 2067

页数：12

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