Regiodivergent Ligand-Controlled Rhodium-Catalyzed [(2+2)+2] Carbocyclization Reactions with Alkyl Substituted Methyl Propiolates

被引：45

作者：

Evans, P. Andrew ^{[1
]}

Sawyer, James R. ^{[2
]}

Inglesby, Phillip A. ^{[1
]}

机构：

[1] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

[2] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 33期

基金：

英国工程与自然科学研究理事会; 美国国家卫生研究院;

关键词：

carbocyclization; diastereoselective; metallacycle; regiodivergent reactions; rhodium; 1,6-ENYNES; CYCLOADDITION; COMPLEXES; COBALT; CONSTRUCTION; DIENES; ENYNES;

D O I：

10.1002/anie.201002117

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Choice is yours: In the title reaction the selective formation of either regioisomer can be controlled through judicious choice of the ancillary ligands (see scheme). Central to this accomplishment was the realization that residual silver salts from the salt metathesis of the neutral complex have a strong effect on the regio- and diastereoselectivity. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5746 / 5749

页数：4

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