Cytotoxic clerodane diterpene esters from Laetia corymbulosa

被引：27

作者：

Beutler, JA

McCall, KL

Herbert, K

Johnson, T

Shoemaker, RH

Boyd, MR ^{[1
]}

机构：

[1] NCI, Frederick Canc Res & Dev Ctr, Lab Drug Discovery Res & Dev, Frederick, MD 21702 USA

[2] NCI, Frederick Canc Res & Dev Ctr, SAIC, Frederick, MD 21702 USA

来源：

PHYTOCHEMISTRY | 2000年 / 55卷 / 03期

关键词：

Laetia corymbulosa; Flacourtiaceae; diterpenoids; corymbulosin A;

D O I：

10.1016/S0031-9422(00)00281-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three cytotoxic cleroodane diterpene esters, corymbulosins A-C, were isolated from an organic extract of the fruit of Laetia corymbulosa (Flacourtiaceae) from Peru. The structures were determined by spectroscopic methods as clerodane diterpenes unsaturated at C-3, C-13(16) and C-14. Corymbulosin A was esterified at C-2 with a decadienoate moiety, while corymbulosins B and C were C-2 epimers esterified at C-6 with a decanoate moiety. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：233 / 236

页数：4

共 8 条

[1] Novel cytotoxic diterpenes from Casearia arborea [J].

Beutler, JA ;

McCall, KL ;

Herbert, K ;

Herald, DL ;

Pettit, GR ;

Johnson, T ;

Shoemaker, RH ;

Boyd, MR .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (05) :657-661

[2] CORYMBOTINS A-I - HIGHLY OXIDIZED KOLOVANE DERIVATIVES FROM CASEARIA-CORYMBOSA [J].

CHEN, TB ;

WIEMER, DF .

JOURNAL OF NATURAL PRODUCTS, 1991, 54 (06) :1612-1618

[3] Clerodane diterpenes from the leaves of Laetia procera [J].

Gibbons, S ;

Gray, AI ;

Waterman, PG .

PHYTOCHEMISTRY, 1996, 43 (03) :635-638

[4]

GUITTET E, 1988, TETRAHEDRON, V44, P2893

[5] IN-VIVO CULTIVATION OF TUMOR-CELLS IN HOLLOW FIBERS [J].

HOLLINGSHEAD, MG ;

ALLEY, MC ;

CAMALIER, RF ;

ABBOTT, BJ ;

MAYO, JG ;

MALSPEIS, L ;

GREVER, MR .

LIFE SCIENCES, 1995, 57 (02) :131-141

[6] Four new clerodane diterpenes from the leaves of Casearia guianensis which inhibit the interaction of leukocyte function antigen 1 with intercellular adhesion molecule 1 [J].

Hunter, MS ;

Corley, DG ;

Carron, CP ;

Rowold, E ;

Kilpatrick, BF ;

Durley, RC .

JOURNAL OF NATURAL PRODUCTS, 1997, 60 (09) :894-899

[7] NEW ANTITUMOR PRINCIPLES, CASEARINS-A-F, FOR CASEARIA-SYLVESTRIS SW (FLACOURTIACEAE) [J].

ITOKAWA, H ;

TOTSUKA, N ;

MORITA, H ;

TAKEYA, K ;

IITAKA, Y ;

SCHENKEL, EP ;

MOTIDOME, M .

CHEMICAL & PHARMACEUTICAL BULLETIN, 1990, 38 (12) :3384-3388

[8] DITERPENES FROM ZUELANIA-GUIDONIA [J].

KHAN, MR ;

GRAY, AI ;

REED, DR ;

SADLER, IH ;

WATERMAN, PG .

PHYTOCHEMISTRY, 1990, 29 (05) :1609-1614

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