Antibodies against phosphorylcholine are not altered in plasma of patients with Alzheimer's disease

被引：1

作者：

Silajdzic, Edina ^{[1
]}

Bjorkqvist, Maria ^{[1
]}

Hansson, Oskar ^{[2
,3
]}

机构：

[1] Lund Univ, Brain Dis Biomarker Unit, Dept Expt Med Sci, Wallenberg Neurosci Ctr, Lund, Sweden

[2] Lund Univ, Clin Memory Res Unit, Dept Clin Sci Malmo, Malmo, Sweden

[3] Skane Univ Hosp, Memory Clin, Malmo, Sweden

来源：

BMC NEUROLOGY | 2015年 / 15卷

基金：

瑞典研究理事会;

关键词：

Anti-phosphorylcholine; Alzheimer's disease; Dementia; Biomarker; VASCULAR RISK-FACTORS; INTERNATIONAL WORKSHOP; IGM ANTIBODIES; DEMENTIA; DIAGNOSIS; PATHOLOGY; CRITERIA; COHORT; LIFE;

D O I：

10.1186/s12883-015-0260-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Phosphorylcholine is one of the major epitopes of oxidised low density lipoprotein. Low levels of IgM antibodies against phosphorylcholine (anti-PC) are associated with development of myocardial infarction and stroke. It has been shown that patients with Alzheimer's disease and other dementias have significantly lower serum anti-PC levels compared to controls, suggesting that low levels of atheroprotective anti-PC may play a role in AD and dementia. Methods: We quantified levels of anti-PC levels using an ELISA in plasma from 176 controls, 125 patients with Alzheimer's disease, 19 patients with vascular dementia and 63 patients with other dementias. Results: We observed similar plasma anti-PC levels in controls, patients with Alzheimer's disease, and other dementias. Conclusions: Our data suggests that anti-PC is not useful as a biomarker for Alzheimer's disease.

引用

页数：5

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