The protective effects of glycyrrhizic acid on heavy metal ions-induced reproductive toxicity in Chinese hamster ovary cells

被引：0
|
作者：
Gao, Liang [1 ]
Liu, Pai [2 ]
Du, Tianqi [1 ]
Yin, Jian [2 ,3 ]
Li, Hong [1 ]
机构：
[1] Nanjing Med Univ, Suzhou Municipal Hosp, Ctr Reprod & Genet, Affiliated Suzhou Hosp, Suzhou 215002, Peoples R China
[2] Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, CAS Key Lab Biomed Diagnost, Suzhou 215163, Peoples R China
[3] Jinan Guo Ke Med Technol Dev Co Ltd, Jinan 250100, Peoples R China
来源：
SCIENCEASIA | 2021年 / 47卷 / 04期
关键词：
Chinese hamster ovary cells; Cd2+; Cu2+; glycyrrhizic acid; oxidative stress; CADMIUM TOXICITY; COPPER; GLUTATHIONE; MATURATION; INTEGRITY; LICORICE; EXPOSURE; EXTRACT; SULFATE;
D O I：
10.2306/scienceasia1513-1874.2021.052
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In this work, Chinese hamster ovary (CHO) cells were used to examine the protective effects of glycyrrhizic acid (GA) on the reproductive toxicity of heavy metal ions, including Cd2+ and Cu2+. As a result, both metal ions induced significant toxicity in CHO cells after 48-h treatment, as revealed by a severe decrease in cell viability. GA and glutathione (GSH) largely reduced the toxicity caused by Cd2+ and Cu2+, which could be due to their recovery of GSH levels and superoxide dismutase (SOD) activities in CHO cells. In addition, GA and GSH significantly up-regulated the gene expressions of glutathione S-transferase (gst), sod, and heme oxygenase (ho)-1, which could be another explanation for their protective effects. More importantly, GA exhibited comparable protective effects as GSH but at much lower concentrations (50-100 mu M vs. 500-1000 mu M). Therefore, GA could be effective for the alleviation of reproductive toxicity of Cd2+/Cu2+, which needs further investigation in animal models.
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页码：410 / +
页数：9
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