Extracellular ubiquitin regulates the growth of human hematopoietic cells

被引：21
作者：
Daino, H
Shibayama, H
Machii, T
Kitani, T
机构：
[1] Dept. of Hematology and Oncology, Osaka University Medical School, Suita
[2] Dept. of Hematology and Oncology, Osaka University Medical School, Suita, Osaka 565
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 223卷 / 02期
关键词：
D O I：
10.1006/bbrc.1996.0875
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the effects of extracellular ubiquitin on the colony formation of human hematopoietic progenitor cells (CFU-GM, CFU-E and BFU-E) and a granulocyte-colony stimulating factor (G-CSF)-dependent human myeloblastic leukemic cell line, OCI/AML/1a. Ubiquitin exhibited inhibitory effects on CFU-GM, CFU-E, BFU-E and OCI/AML/1a colony formation. Extracellular ubiquitin also inhibited the growth of KT3 (T lymphoblast), K562 (erythroleukemia) and Daudi (Burkitt's lymphoma) cells, stimulated the growth of HL60 (promyelocytic leukemia) and Jurkat (T-ALL) cells and showed no effect on the growth of U937 cells (monocytic leukemia). These results indicate that another, previously unrecognized function of extracellular ubiquitin is to regulate hematopoiesis. (C) 1996 Academic Press, Inc.
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页码：226 / 228
页数：3
相关论文
共 13 条
  • [1] BOURONCLE BA, 1979, BLOOD, V53, P412
  • [2] CIECHANOVER A, 1994, BIOL CHEM H-S, V375, P565
  • [3] DAINIAK N, 1994, EXP HEMATOL, V22, P339
  • [4] THE UBIQUITIN PATHWAY FOR PROTEIN-DEGRADATION
    HERSHKO, A
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 1991, 16 (07) : 265 - 268
  • [5] HIRATA Y, 1989, J IMMUNOL, V143, P2900
  • [6] UBIQUITIN, PROTEASOMES, AND THE REGULATION OF INTRACELLULAR PROTEIN-DEGRADATION
    HOCHSTRASSER, M
    [J]. CURRENT OPINION IN CELL BIOLOGY, 1995, 7 (02) : 215 - 223
  • [7] FUNCTIONAL EXPRESSION OF FAS ANTIGEN (CD95) ON HEMATOPOIETIC PROGENITOR CELLS
    NAGAFUJI, K
    SHIBUYA, T
    HARADA, M
    MIZUNO, S
    TAKENAKA, K
    MIYAMOTO, T
    OKAMURA, T
    GONDO, H
    NIHO, Y
    [J]. BLOOD, 1995, 86 (03) : 883 - 889
  • [8] Nakamura M, 1996, J IMMUNOL, V156, P533
  • [9] GRANULOCYTE COLONY-STIMULATING FACTOR-DEPENDENT GROWTH OF AN ACUTE MYELOBLASTIC-LEUKEMIA CELL-LINE
    NARA, N
    SUZUKI, T
    NAGATA, K
    TOHDA, S
    YAMASHITA, Y
    NAKAMURA, Y
    IMAI, Y
    MORIO, T
    MINAMIHISAMATSU, M
    [J]. JAPANESE JOURNAL OF CANCER RESEARCH, 1990, 81 (6-7): : 625 - 631
  • [10] EFFECT OF UBIQUITIN ON PLATELET FUNCTIONS - POSSIBLE IDENTITY WITH PLATELET ACTIVITY SUPPRESSIVE LYMPHOKINE (PASL)
    PANCRE, V
    PIERCE, RJ
    FOURNIER, F
    MEHTALI, M
    DELANOYE, A
    CAPRON, A
    AURIAULT, C
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1991, 21 (11) : 2735 - 2741
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