Mitochondrial oxidant signalling in Alzheimer's disease

被引：0

作者：

Vina, Jose ^{[1
]}

Lloret, Ana ^{[1
]}

Valles, Soraya L. ^{[1
]}

Borras, Consuelo ^{[1
]}

Badia, Mari-Carmen ^{[1
]}

Pallardo, Federico V. ^{[1
]}

Sastre, Juan ^{[1
]}

Alonso, Maria-Dolores ^{[1
]}

机构：

[1] Fac Med, Dept Fisiol, Valencia 46010, Spain

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2007年 / 11卷 / 02期

关键词：

apoptosis; gender; estrogenic compounds; antioxidants; MAP kinases;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of free radicals in Alzheimer disease pathophysiology has been appreciated for a long time. Originally, radicals were considered as causative of oxidative damage. More recently their role as signalling molecules in this, as well as in other fields of free radical biology, has been underscored. Mitochondria are both generators and targets of radical damage in aging. In this paper we review evidence that radicals generated in mitochondria in the presence of A beta are signals that trigger both the mitochondrial and the extra-mitochondrial pathways of apoptosis. There are gender specific differences in mitochondrial A beta toxicity: mitochondria from young (but not from old) females appear to be protected. 17-beta Estradiol or phytoestrogens like genistein prevent the formation of oxidants by mitochondria and protect against mitochondrial A beta toxicity. Experiments reported here indicate that phytoestrogens might have a role in the prevention of Alzheimer's disease.

引用

页码：175 / 181

页数：7

共 22 条

[1] Mitochondrial free radical production and aging in mammals and birds [J].