PK11195, a mitochondrial benzodiazepine receptor antagonist, as a new therapy for CLL.

被引:0
|
作者
Auer, RL
Fennell, DA
Corbo, M
Fegan, CD
Lister, A
Cotter, FE
机构
[1] St Barts & Royal London Sch Med, Dept Expt Haematol, London, England
[2] St Barts, ICRF Dept Med Oncol, London, England
[3] Birmingham Heartlands Hosp, Dept Haematol, Birmingham B9 5ST, W Midlands, England
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
2220
引用
收藏
页码:516A / 516A
页数:1
相关论文
共 50 条
  • [41] High-affinity peripheral benzodiazepine receptor ligand, PK11195, regulates protein phosphorylation in rat brain mitochondria under control of Ca2+
    Azarashvili, T
    Krestinina, O
    Yurkov, I
    Evtodienko, Y
    Reiser, G
    JOURNAL OF NEUROCHEMISTRY, 2005, 94 (04) : 1054 - 1062
  • [42] Imaging brain inflammation with [11C]PK11195 by PET and induction of the peripheral-type benzodiazepine receptor after transient focal ischemia in rats
    Rojas, Santiago
    Martin, Abraham
    Arranz, Maria J.
    Pareto, Deborah
    Purroy, Jesus
    Verdaguer, Esther
    Llop, Jordi
    Gomez, Vanessa
    Gispert, Joan D.
    Millan, Olga
    Chamorro, Angel
    Planas, Anna M.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2007, 27 (12): : 1975 - 1986
  • [43] Release of p53 from mitochondrial matrix to the nucleus during cellula stress: Influence of PK11195
    Green, M. L.
    Singh, A., V
    Knudsen, T. B.
    BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 2007, 79 (05) : 355 - 355
  • [44] Rotational barriers in the peripheral benzodiazepine receptor ligand, PK 11195:: Determination by quantum chemistry and NMR
    Pike, VW
    Briard, E
    Siméon, FG
    Shetty, HU
    Lee, YS
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U2525 - U2525
  • [45] The benzodiazepine receptor antagonist PK 11195 alters diazepam-induced changes of tetanic contractions in the rat phrenic nerve-diaphragm preparation
    vanWeerenKramer, J
    vanHamme, J
    Leeuwin, RS
    vanWilgenburg, H
    NEUROSCIENCE RESEARCH COMMUNICATIONS, 1997, 21 (02) : 93 - 102
  • [46] Competition of PK11195 with the peripheral benzodiazepine receptor ligands [18F]PBR102 and [18F]PBR111 in rats and baboons
    Katsifis, Andrew
    Eberi, Stefan
    Mattner, Filomena
    Loc'h, Christian
    Gregoire, Marie-Claude
    Greguric, Ivan
    Henderson, David
    Tien Pham
    Verschuer, Jordan
    Fulham, Michael
    JOURNAL OF NUCLEAR MEDICINE, 2009, 50
  • [47] The effect of PK 11195, a specific antagonist of the peripheral benzodiazepine receptors, on body weight in rats chronically exposed to diazepam
    Jing, X
    Wala, EP
    Sloan, JW
    PHARMACOLOGICAL RESEARCH, 2000, 42 (03) : 227 - 233
  • [48] Up-regulation of the peripheral-type benzodiazepine receptor expression and [3H]PK11195 binding in gerbil hippocampus after transient forebrain ischemia
    Rao, VLR
    Bowen, KK
    Rao, AM
    Dempsey, RJ
    JOURNAL OF NEUROSCIENCE RESEARCH, 2001, 64 (05) : 493 - 500
  • [49] A PERIPHERAL ANTAGONIST OF BENZODIAZEPINE RECEPTORS (PK-11195) DID NOT REVERSE BEHAVIORAL-EFFECTS OF DIAZEPAM IN MICE
    SULCOVA, A
    KRSIAK, M
    ACTIVITAS NERVOSA SUPERIOR, 1989, 31 (04): : 295 - 296
  • [50] PK ('peripheral benzodiazepine') - Binding sites in the CNS indicate early and discrete brain lesions: Microautoradiographic detection of [H-3]PK11195 binding to activated microglia
    Banati, RB
    Myers, R
    Kreutzberg, GW
    JOURNAL OF NEUROCYTOLOGY, 1997, 26 (02): : 77 - 82