A recombinant rubella virus E1 glycoprotein as a rubella vaccine candidate

被引：8

作者：

Perrenoud, G

Messerli, E

Thierry, AC

Beltraminelli, N

Cousin, P

Fasel, N

Vallet, V

Demotz, S

Duchosal, MA

Moulon, C

机构：

[1] Dictagene, CH-1000 Lausanne 25, Switzerland

[2] Univ Lausanne, Inst Biochem, CH-1066 Epalinges, Switzerland

[3] Univ Lausanne Hosp, Serv Haematol, Lausanne, Switzerland

来源：

VACCINE | 2004年 / 23卷 / 04期

关键词：

rubella virus; recombinant E1 glycoprotein; vaccine;

D O I：

10.1016/j.vaccine.2004.06.030

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A recombinant rubella virus E1 (rE1) glycoprotein was produced and some of its chemical and immunological features were characterized. Two animal models were then used to establish that the rE1 glycoprotein and rubella virus particles shared antigenic and immunogenic properties. In the first one, sera from rE1 glycoprotein-immunized BALB/c mice neutralized in vitro rubella virus infection. In the second model, severe combined immune deficient (SCID) mice implanted with tonsil fragments from rubella immune donors and immunized with rE1 glycoprotein produced human anti-rubella virus antibodies. Altogether, these results showed that immunization with rE1 glycoprotein elicited neutralizing anti-rubella virus antibodies. This study thus indicated that the rE1 glycoprotein could constitute a non-replicating rubella vaccine. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：480 / 488

页数：9

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