EFFECT OF FREQUENCY-DEPENDENT ATTENUATION ON PREDICTED HISTOTRIPSY WAVEFORMS IN TISSUE-MIMICKING PHANTOMS

被引：23

作者：

Bader, Kenneth B. ^{[1
]}

Crowe, Michael J. ^{[2
]}

Raymond, Jason L. ^{[2
]}

Holland, Christy K. ^{[1
,2
]}

机构：

[1] Univ Cincinnati, Dept Internal Med, Div Cardiovasc Hlth & Dis, Cincinnati, OH USA

[2] Univ Cincinnati, Biomed Engn Program, Cincinnati, OH USA

来源：

ULTRASOUND IN MEDICINE AND BIOLOGY | 2016年 / 42卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Histotripsy; Shock waves; Ultrasonic attenuation; Acoustical properties; Cavitation; THERAPEUTIC ULTRASOUND FIELDS; EROSION; LIVER;

D O I：

10.1016/j.ultrasmedbio.2016.02.010

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

Tissue-mimicking phantoms are employed for the assessment of shocked histotripsy pulses in vitro. These broadband shock waves are critical for tissue ablation and are influenced by the frequency-dependent attenuation of the medium. The density, sound speed and attenuation spectra (2-25 MHz) were measured for phantoms that mimic key histotripsy targets. The influence of non-linear propagation relative to the attenuation was described in terms of Gol'dberg number. An expression was derived to estimate the bandwidth of shocked histotripsy pulses for power law-dependent attenuation. The expression is independent of the fundamental frequency of the histotripsy pulse for linear frequency-dependent attenuation. (E-mail: christy.holland@uc.edu) (C) 2016 World Federation for Ultrasound in Medicine & Biology.

引用

页码：1701 / 1705

页数：5

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