Feedback control of intercellular signalling in development

被引：397
作者：
Freeman, M [1 ]
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
来源：
NATURE | 2000年 / 408卷 / 6810期
关键词：
D O I：
10.1038/35042500
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The intercellular communication that regulates cell fate during animal development must be precisely controlled to avoid dangerous errors. How is this achieved? Recent work has highlighted the importance of positive and negative feedback loops in the dynamic regulation of developmental signalling. These feedback interactions can impart precision, robustness and versatility to intercellular signals. Feedback failure can cause disease.
引用
收藏
页码：313 / 319
页数：7
相关论文
共 85 条
[71]   Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein [J].
Stroschein, SL ;
Wang, W ;
Zhou, SL ;
Zhou, Q ;
Luo, KX .
SCIENCE, 1999, 286 (5440) :771-774
[72]   HEDGEHOG IS A SIGNALING PROTEIN WITH A KEY ROLE IN PATTERNING DROSOPHILA IMAGINAL DISKS [J].
TABATA, T ;
KORNBERG, TB .
CELL, 1994, 76 (01) :89-102
[73]   INDIRECT AUTOREGULATION OF A HOMEOTIC DROSOPHILA GENE MEDIATED BY EXTRACELLULAR SIGNALING [J].
THURINGER, F ;
BIENZ, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (09) :3899-3903
[74]  
TREMML G, 1992, DEVELOPMENT, V116, P447
[75]   Daughters against dpp modulates dpp organizing activity in Drosophila wing development [J].
Tsuneizumi, K ;
Nakayama, T ;
Kamoshida, Y ;
Kornberg, TB ;
Christian, JL ;
Tabata, T .
NATURE, 1997, 389 (6651) :627-631
[76]   THE CHEMICAL BASIS OF MORPHOGENESIS [J].
TURING, AM .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1952, 237 (641) :37-72
[77]   smoothened encodes a serpentine protein required for hedgehog signalling [J].
vandenHeuvel, M ;
Ingham, PW .
NATURE, 1996, 382 (6591) :547-551
[78]   Canalization of development and the inheritance of acquired characters [J].
Waddington, CH .
NATURE, 1942, 150 :563-565
[79]   An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg [J].
Wasserman, JD ;
Freeman, M .
CELL, 1998, 95 (03) :355-364
[80]   A MODEL OF GROWTH AND GROWTH CONTROL IN MATHEMATICAL TERMS [J].
WEISS, P ;
KAVANAU, JL .
JOURNAL OF GENERAL PHYSIOLOGY, 1957, 41 (01) :1-47
123456789