Pathological Role of Natural Killer Cells in Parkinson's Disease: A Systematic Review

被引：5

作者：

Zhang, Le ^{[1
,2
]}

Zhang, Yingshuang ^{[1
]}

Fan, Dongsheng ^{[1
,3
,4
]}

机构：

[1] Peking Univ Third Hosp, Dept Neurol, Beijing, Peoples R China

[2] Peking Univ Hlth Sci Ctr, Beijing, Peoples R China

[3] Beijing Key Lab Biomarker & Translat Res Neurodege, Beijing, Peoples R China

[4] Peking Univ, Key Lab Neurosci, Natl Hlth Commiss, Minist Educ, Beijing, Peoples R China

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2022年 / 14卷

关键词：

Parkinson's disease; alpha-synuclein; natural killer cells; natural killer cell cytotoxicity; neuroinflammation; ALPHA-SYNUCLEIN; AGE; AUTOIMMUNE;

D O I：

10.3389/fnagi.2022.890816

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Parkinson's disease (PD) is one of the common neurodegenerative diseases that is characterized by selective degeneration of dopaminergic neurons in the substantia nigra, and misfolding of alpha-synuclein into aggregates is thought to contribute to its pathology. Studies have shown that immune-inflammatory responses are involved in the development of PD and play an important role in alpha-synuclein scavenge. Natural killer (NK) cells are first responders in immune cells and can directly promote immune defense mechanisms by cytotoxicity and by secreting cytokines. Recent discoveries suggest that NK cells are increasingly recognized in the pathological features of PD. However, the mechanisms underlying it have not been fully understood. In this review, we systematically retrieved and evaluated published evidence about the functions of NK cells in PD. We find alterations in the number of NK cells and cytotoxicity during the progression of PD, and it seems that NK cells play a neuroprotective role in PD pathogenesis, which may further reveal novel targets for the management and treatment of PD.

引用

页数：10

共 43 条

[1] Natural Killer Cells: Development, Maturation, and Clinical Utilization [J].

Abel, Alex M. ;

Yang, Chao ;

Thakar, Monica S. ;

Malarkannan, Subramaniam .

FRONTIERS IN IMMUNOLOGY, 2018, 9

[2] Killer Cell Immunoglobulin-like Receptor Variants Are Associated with Protection from Symptoms Associated with More Severe Course in Parkinson Disease [J].

Anderson, Kirsten M. ;

Augusto, Danillo G. ;

Dandekar, Ravi ;

Shams, Hengameh ;

Zhao, Chao ;

Yusufali, Tasneem ;

Montero-Martin, Gonzalo ;

Marin, Wesley M. ;

Nemat-Gorgani, Neda ;

Creary, Lisa E. ;

Caillier, Stacy ;

Mofrad, Mohammad R. K. ;

Parham, Peter ;

Fernandez-Vina, Marcelo ;

Oksenberg, Jorge R. ;

Norman, Paul J. ;

Hollenbach, Jill A. .

JOURNAL OF IMMUNOLOGY, 2020, 205 (05) :1323-1330

[3] Dopamine, a neurotransmitter, influences the immune system [J].

Basu, S ;

Dasgupta, PS .

JOURNAL OF NEUROIMMUNOLOGY, 2000, 102 (02) :113-124

[4] Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms [J].

Blauwendraat, Cornelis ;

Heilbron, Karl ;

Vallerga, Costanza L. ;

Bandres-Ciga, Sara ;

von Coelln, Rainer ;

Pihlstrom, Lasse ;

Simon-Sanchez, Javier ;

Schulte, Claudia ;

Sharma, Manu ;

Krohn, Lynne ;

Siitonen, Ari ;

Iwaki, Hirotaka ;

Leonard, Hampton ;

Noyce, Alastair J. ;

Tan, Manuela ;

Gibbs, J. Raphael ;

Hernandez, Dena G. ;

Scholz, Sonja W. ;

Jankovic, Joseph ;

Shulman, Lisa M. ;

Lesage, Suzanne ;

Corvol, Jean-Christophe ;

Brice, Alexis ;

van Hilten, Jacobus J. ;

Marinus, Johan ;

Eerola-Rautio, Johanna ;

Tienari, Pentti ;

Majamaa, Kari ;

Toft, Mathias ;

Grosset, Donald G. ;

Gasser, Thomas ;

Heutink, Peter ;

Shulman, Joshua M. ;

Wood, Nicolas ;

Hardy, John ;

Morris, Huw R. ;

Hinds, David A. ;

Gratten, Jacob ;

Visscher, Peter M. ;

Gan-Or, Ziv ;

Nalls, Mike A. ;

Singleton, Andrew B. .

MOVEMENT DISORDERS, 2019, 34 (06) :866-875

[5] ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY (ADCC) IN PARKINSONS-DISEASE [J].

BOKOR, M ;

FARAGO, A ;

GARAM, T ;

MALATINSZKY, G ;

SCHNABEL, R .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1993, 115 (01) :47-50

[6] A nationwide study of the incidence, prevalence and mortality of Parkinson's disease in the Norwegian population [J].

Brakedal, Brage ;

Toker, Lilah ;

Haugarvoll, Kristoffer ;

Tzoulis, Charalampos .

NPJ PARKINSONS DISEASE, 2022, 8 (01)

[7] Regulation of natural killer cell activity by glucocorticoids, serotonin, dopamine, and epinephrine [J].

Capellino, Silvia ;

Claus, Maren ;

Watzl, Carsten .

CELLULAR & MOLECULAR IMMUNOLOGY, 2020, 17 (07) :705-711

[8] Peripheral Lymphocyte Subsets as a Marker of Parkinson's Disease in a Chinese Population [J].

Cen, Luan ;

Yang, Chaohao ;

Huang, Shuxuan ;

Zhou, Miaomiao ;

Tang, Xiaolu ;

Li, Kaiping ;

Guo, Wenyuan ;

Wu, Zhuohua ;

Mo, Mingshu ;

Xiao, Yousheng ;

Chen, Xiang ;

Yang, Xinling ;

Huang, Qinhui ;

Chen, Chaojun ;

Qu, Shaogang ;

Xu, Pingyi .

NEUROSCIENCE BULLETIN, 2017, 33 (05) :493-500

[9] The role of T cells in the pathogenesis of Parkinson's disease [J].

Chen, Zhichun ;

Chen, Shengdi ;

Liu, Jun .

PROGRESS IN NEUROBIOLOGY, 2018, 169 :1-23

[10] Microglia clear neuron-released a-synuclein via selective autophagy and prevent neurodegeneration [J].

Choi, Insup ;

Zhang, Yuanxi ;

Seegobin, Steven P. ;

Pruvost, Mathilde ;

Wang, Qian ;

Purtell, Kerry ;

Zhang, Bin ;

Yue, Zhenyu .

NATURE COMMUNICATIONS, 2020, 11 (01)

← 1 2 3 4 5 →