Signaling pathways in induced naive pluripotency

被引：21

作者：

Ye, Shoudong ^{[1
,2
]}

Liu, Dahai ^{[1
]}

Ying, Qi-Long ^{[2
]}

机构：

[1] Anhui Univ, Sch Life Sci, Ctr Stem Cell & Translat Med, Hefei 230601, Peoples R China

[2] Univ So Calif, Keck Sch Med, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Dept Stem Cell Biol & Regenerat Med, Los Angeles, CA 90033 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2014年 / 28卷

基金：

美国国家卫生研究院;

关键词：

EMBRYONIC STEM-CELLS; GROUND-STATE; SELF-RENEWAL; SOMATIC-CELLS; ACTIVATION; INDUCTION; TARGET; FIBROBLASTS; INHIBITION; NANOG;

D O I：

10.1016/j.gde.2014.08.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pluripotent stem cells have become powerful tools for both research and regenerative medicine. To date, however, only mouse and rat embryonic stem cells (ESCs)/induced pluripotent stem cells (iPSCs) have the ability to contribute to the formation of germline-competent chimeras. These stem cells are thus considered as `naive' pluripotent stem cells. Several signaling pathways have been identified to play a critical role in the induction and maintenance of this naive pluripotent state. Understanding how these pathways induce and maintain naive pluripotency will likely lead to the generation of germline-competent naive ESCs/iPSCs from humans and animals phylogenetically close to humans.

引用

页码：10 / 15

页数：6

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