Signaling pathways in induced naive pluripotency

被引：21
|
作者：
Ye, Shoudong [1 ,2 ]
Liu, Dahai [1 ]
Ying, Qi-Long [2 ]
机构：
[1] Anhui Univ, Sch Life Sci, Ctr Stem Cell & Translat Med, Hefei 230601, Peoples R China
[2] Univ So Calif, Keck Sch Med, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Dept Stem Cell Biol & Regenerat Med, Los Angeles, CA 90033 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2014年 / 28卷
基金：
美国国家卫生研究院;
关键词：
EMBRYONIC STEM-CELLS; GROUND-STATE; SELF-RENEWAL; SOMATIC-CELLS; ACTIVATION; INDUCTION; TARGET; FIBROBLASTS; INHIBITION; NANOG;
D O I：
10.1016/j.gde.2014.08.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Pluripotent stem cells have become powerful tools for both research and regenerative medicine. To date, however, only mouse and rat embryonic stem cells (ESCs)/induced pluripotent stem cells (iPSCs) have the ability to contribute to the formation of germline-competent chimeras. These stem cells are thus considered as `naive' pluripotent stem cells. Several signaling pathways have been identified to play a critical role in the induction and maintenance of this naive pluripotent state. Understanding how these pathways induce and maintain naive pluripotency will likely lead to the generation of germline-competent naive ESCs/iPSCs from humans and animals phylogenetically close to humans.
引用
收藏
页码：10 / 15
页数：6
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