Determinants of oxygen utilization in breast cancer: Similarities between heart failure with preserved ejection fraction

被引：13

作者：

Haykowsky, Mark J. ^{[1
]}

Kirkham, Amy A. ^{[2
]}

Li, Todd ^{[1
]}

Pituskin, Edith ^{[1
]}

Thompson, Richard B. ^{[3
]}

Paterson, D. Ian ^{[4
]}

Foulkes, Stephen J. ^{[1
,5
]}

Martin, Halle ^{[6
]}

Sarma, Satyam ^{[7
,8
]}

Howden, Erin

Nelson, Michael D. ^{[9
]}

La Gerche, Andre ^{[5
,10
,11
]}

机构：

[1] Univ Alberta, Fac Nursing, Edmonton, AB, Canada

[2] Univ Toronto, Fac Kinesiol & Phys Educ, Toronto, ON, Canada

[3] Univ Alberta, Dept Biomed Engn, Fac Med & Dent, Edmonton, AB, Canada

[4] Univ Alberta, Fac Med & Dent, Div Cardiol, Edmonton, AB, Canada

[5] Baker Heart & Diabet Inst, Clin Res Domain, Melbourne, Vic, Australia

[6] Tech Univ Munich, Sch Med, Dept Prevent & Sports Med, Munich, Germany

[7] Univ Texas SouthWestern, Dept Internal Med, Dallas, TX USA

[8] Texas Hlth Presbyterian Hosp, Inst Exercise & Environm Med, Dallas, TX USA

[9] Univ Texas Arlington, Coll Nursing & Hlth Innovat, Arlington, TX USA

[10] Univ Melbourne, Fac Med Dent & Hlth Sci, Parkville, Vic, Australia

[11] St Vincents Hosp, Dept Cardiol, Fitzroy, Vic, Australia

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 2022年 / 74卷

关键词：

Breast Cancer; Heart failure with preserved ejection fraction; Peak oxygen uptake; Oxygen transport; MEDIATED ARTERIAL DILATION; EXERCISE INTOLERANCE; OLDER PATIENTS; ANTHRACYCLINE CHEMOTHERAPY; ENDOTHELIAL FUNCTION; RISK PROFILE; CAPACITY; WOMEN; STIFFNESS; SURVIVORS;

D O I：

10.1016/j.pcad.2022.10.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Reduced exercise tolerance and fatigue are hallmark features in both breast cancer (BC) and heart failure with preserved ejection fraction (HFpEF) and are associated with decreased physical function and quality of life. This brief review focuses on the mechanisms of exercise intolerance in women with BC across the survivorship continuum and highlights how these disturbances within the oxygen transport cascade are similar to that of HFpEF patients. Specifically, the role that impaired cardiac, peripheral vascular and skeletal muscle function play in limiting peak oxygen uptake are discussed. We propose that women with BC are at increased risk of developing HFpEF potentially due to the adverse effects of chemotherapy and concurrent adverse lifestyle behaviors on cardiovascular and skeletal muscle function. (c) 2022 Elsevier Inc. All rights reserved.

引用

页码：45 / 52

页数：8

共 68 条

[1] Physiological Factors Important to Cardiorespiratory Fitness are Similar Between Breast Cancer Survivors and Controls [J].