Role of Glucocorticoids in Cystic Ovarian Disease: Expression of Glucocorticoid Receptor in the Bovine Ovary

被引：11
|
作者：
Amweg, Ayelen N. [1 ,2 ]
Rodriguez, Fernanda M. [1 ]
Huber, Emilia [1 ]
Marelli, Belkis E. [1 ]
Salvetti, Natalia R. [1 ]
Rey, Florencia [1 ]
Ortega, Hugo H. [1 ]
机构：
[1] UNL, CONICET, Inst Ciencias Vet Litoral ICiVet Litoral, Lab Biol Celular & Mol Aplicada, RA-3080 Esperanza, Santa Fe, Argentina
[2] Fdn Bunge & Born, Buenos Aires, DF, Argentina
来源：
CELLS TISSUES ORGANS | 2015年 / 201卷 / 02期
关键词：
Bovine ovary; Cystic ovarian disease; Glucocorticoid receptor; Ovarian cysts; GROWTH-FACTOR-I; GENE-EXPRESSION; HORMONAL-REGULATION; CELL-PROLIFERATION; FOLLICULAR CYSTS; CORPUS-LUTEUM; DAIRY-COWS; CORTISOL; FOLLICLES; APOPTOSIS;
D O I：
10.1159/000442150
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
The aim of this study was to characterize the expression of glucocorticoid receptor (GR) in the components of normal bovine ovary and in animals with cystic ovarian disease (COD). Changes in the protein and mRNA expression levels were determined in control cows and cows with COD by immunohistochemistry and real-time PCR. GR protein expression in granulosa cells was higher in cysts from animals with spontaneous COD and adrenocorticotropic hormone-induced COD than in tertiary follicles from control animals. In theca interna cells, GR expression was higher in cysts from animals with spontaneous COD than in tertiary follicles from control animals. The increase in GR expression observed in cystic follicles suggests a mechanism of action for cortisol and its receptor through the activation/inactivation of specific transcription factors. These factors could be related to the pathogenesis of COD in cattle. (C) 2015 S. Karger AG, Basel
引用
收藏
页码：138 / 147
页数：10
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