Role of Glucocorticoids in Cystic Ovarian Disease: Expression of Glucocorticoid Receptor in the Bovine Ovary

被引：11
|
作者：
Amweg, Ayelen N. [1 ,2 ]
Rodriguez, Fernanda M. [1 ]
Huber, Emilia [1 ]
Marelli, Belkis E. [1 ]
Salvetti, Natalia R. [1 ]
Rey, Florencia [1 ]
Ortega, Hugo H. [1 ]
机构：
[1] UNL, CONICET, Inst Ciencias Vet Litoral ICiVet Litoral, Lab Biol Celular & Mol Aplicada, RA-3080 Esperanza, Santa Fe, Argentina
[2] Fdn Bunge & Born, Buenos Aires, DF, Argentina
来源：
CELLS TISSUES ORGANS | 2015年 / 201卷 / 02期
关键词：
Bovine ovary; Cystic ovarian disease; Glucocorticoid receptor; Ovarian cysts; GROWTH-FACTOR-I; GENE-EXPRESSION; HORMONAL-REGULATION; CELL-PROLIFERATION; FOLLICULAR CYSTS; CORPUS-LUTEUM; DAIRY-COWS; CORTISOL; FOLLICLES; APOPTOSIS;
D O I：
10.1159/000442150
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
The aim of this study was to characterize the expression of glucocorticoid receptor (GR) in the components of normal bovine ovary and in animals with cystic ovarian disease (COD). Changes in the protein and mRNA expression levels were determined in control cows and cows with COD by immunohistochemistry and real-time PCR. GR protein expression in granulosa cells was higher in cysts from animals with spontaneous COD and adrenocorticotropic hormone-induced COD than in tertiary follicles from control animals. In theca interna cells, GR expression was higher in cysts from animals with spontaneous COD than in tertiary follicles from control animals. The increase in GR expression observed in cystic follicles suggests a mechanism of action for cortisol and its receptor through the activation/inactivation of specific transcription factors. These factors could be related to the pathogenesis of COD in cattle. (C) 2015 S. Karger AG, Basel
引用
收藏
页码：138 / 147
页数：10
相关论文
共 50 条
  • [1] An Overview of Bovine Cystic Ovarian Disease
    Channo, Abdullah
    Kaka, Asmatullah
    Kalwar, Qudratullah
    Jamali, Imdadullah
    Jelani, Ghulam
    Bakhsh, Muhammad
    Dahri, Ghulam Nabi
    Goil, Jai Parkash
    PAKISTAN JOURNAL OF ZOOLOGY, 2022, 54 (05) : 2437 - 2444
  • [2] Steroid receptor mRNA expression in the ovarian follicles of cows with cystic ovarian disease
    Alfaro, Natalia S.
    Salvetti, Natalia R.
    Velazquez, Melisa M.
    Stangaferro, Matias L.
    Rey, Florencia
    Ortega, Hugo H.
    RESEARCH IN VETERINARY SCIENCE, 2012, 92 (03) : 478 - 485
  • [3] Altered Expression of Transforming Growth Factor-Beta Isoforms in Bovine Cystic Ovarian Disease
    Matiller, V.
    Stangaferro, M. L.
    Diaz, P. U.
    Ortega, H. H.
    Rey, F.
    Huber, E.
    Salvetti, N. R.
    REPRODUCTION IN DOMESTIC ANIMALS, 2014, 49 (05) : 813 - 823
  • [4] Heat shock protein patterns in the bovine ovary and relation with cystic ovarian disease
    Velazquez, Melisa M. L.
    Alfaro, Natalia S.
    Dupuy, Carlos R. F.
    Salvetti, Natalia R.
    Rey, Florencia
    Ortega, Hugo H.
    ANIMAL REPRODUCTION SCIENCE, 2010, 118 (2-4) : 201 - 209
  • [5] Involvement of Matrix Metalloproteinases and their Inhibitors in Bovine Cystic Ovarian Disease
    Peralta, M. B.
    Baravalle, M. E.
    Belotti, E. M.
    Stassi, A. F.
    Salvetti, N. R.
    Ortega, H. H.
    Rey, F.
    Velazquez, M. M. L.
    JOURNAL OF COMPARATIVE PATHOLOGY, 2017, 156 (2-3) : 191 - 201
  • [6] Expression of enzymes related with the metabolism of the glucocorticoids in bovine ovarian tissue
    Lopez C, Michael
    Amweg, Ayelen
    Stangaferro, Matias
    Ortega, Hugo
    REVISTA MVZ CORDOBA, 2013, 18 (01) : 3379 - 3386
  • [7] Role of glucocorticoids and glucocorticoid receptor in priming of macrophages caused by glucocorticoid receptor blockade
    Xiao-Yan Zhu
    Yu-Jian Liu
    Fei Diao
    Jie Fan
    Jian Lu
    Ren-Bao Xu
    Endocrine, 2007, 31 : 130 - 137
  • [8] Role of Glucocorticoids and glucocorticoid receptor in priming of macrophages caused by glucocorticoid receptor blockade
    Zhu, Xiao-Yan
    Liu, Yu-Jian
    Diao, Fei
    Fan, Jie
    Lu, Jian
    Xu, Ren-Bao
    ENDOCRINE, 2007, 31 (02) : 130 - 137
  • [9] Role of activin, inhibin, and follistatin in the pathogenesis of bovine cystic ovarian disease
    Stangaferro, Matias L.
    Matiller, Valentina
    Diaz, Pablo U.
    Ortega, Hugo H.
    Rey, Florencia
    Rodriguez, Fernanda M.
    Silva, Manuel A.
    Salvetti, Natalia R.
    ANIMAL REPRODUCTION SCIENCE, 2014, 148 (3-4) : 97 - 108
  • [10] Interaction between IGF1 and IGFBPs in bovine cystic ovarian disease
    Rodriguez, F. M.
    Salvetti, N. R.
    Colombero, M.
    Stangaferro, M. L.
    Barbeito, C. G.
    Ortega, H. H.
    Rey, F.
    ANIMAL REPRODUCTION SCIENCE, 2013, 140 (1-2) : 14 - 25
12345