Insulin Regulation of Myocardial Autophagy

被引：28
作者：
Riehle, Christian [1 ]
Abel, E. Dale [1 ]
机构：
[1] Univ Iowa, Roy J & Lucille A Carver Coll Med, Div Endocrinol & Metab, Fraternal Order Eagles Diabet Res Ctr, Iowa City, IA 52242 USA
来源：
CIRCULATION JOURNAL | 2014年 / 78卷 / 11期
基金：
美国国家卫生研究院;
关键词：
Autophagy; Diabetes mellitus; Insulin; Left ventricular dysfunction; INDUCED CARDIAC-HYPERTROPHY; STARVATION-INDUCED AUTOPHAGY; FATTY-ACID TRANSPORTERS; CONTRACTILE DYSFUNCTION; SIGNALING PATHWAY; GLUCOSE-UPTAKE; HEART-FAILURE; RECEPTOR; CARDIOMYOCYTES; MECHANISMS;
D O I：
10.1253/circj.CJ-14-1080
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Autophagy is a conserved cellular process that plays an important role in cardiovascular homeostasis. Basal levels of autophagy are required for the maintenance of organellar quality control. Autophagy is dynamically regulated in the heart in the fasting to re-feeding transition. Insulin signaling plays an important role in the regulation of myocardial fuel metabolism, mitochondrial function and cellular growth. Recent studies have suggested an important role for insulin signaling in the regulation of myocardial autophagy. This dynamic regulation of autophagy induction during fasting may contribute to organellar homeostasis and if perturbed under conditions of hyperinsulinemia could contribute to accelerated cardiac aging.
引用
收藏
页码：2569 / 2576
页数：8
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