Recent Progress in the Design and Medical Application of In Situ Self-Assembled Polypeptide Materials

被引：23
|
作者：
Wang, Tian-Tian [1 ]
Xia, Yi-Yi [2 ]
Gao, Jian-Qing [2 ]
Xu, Dong-Hang [1 ]
Han, Min [2 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Pharm, Hangzhou 310058, Peoples R China
[2] Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmaceut, Hangzhou 310058, Peoples R China
来源：
PHARMACEUTICS | 2021年 / 13卷 / 05期
基金：
国家重点研发计划;
关键词：
polypeptide; self-assembly; medical applications; SMALL MOLECULES; PEPTIDE HYDROGELS; COMMON MECHANISM; CANCER-THERAPY; DRUG-DELIVERY; INHIBIT; NANOPARTICLES; TRANSFORMATION; CONSTRUCTION; COMBINATION;
D O I：
10.3390/pharmaceutics13050753
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Inspired by molecular self-assembly, which is ubiquitous in natural environments and biological systems, self-assembled peptides have become a research hotspot in the biomedical field due to their inherent biocompatibility and biodegradability, properties that are afforded by the amide linkages forming the peptide backbone. This review summarizes the biological advantages, principles, and design strategies of self-assembled polypeptide systems. We then focus on the latest advances in in situ self-assembly of polypeptides in medical applications, such as oncotherapy, materials science, regenerative medicine, and drug delivery, and then briefly discuss their potential challenges in clinical treatment.
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页数：19
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