Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design

被引:9
作者
Li, Jinhan [1 ]
Luo, Yuemei [1 ]
Wang, Xianghong [1 ]
Wang, Nanshuo [1 ]
Bo, En [1 ]
Chen, Si [1 ]
Chen, Shufen [1 ]
Chen, Shi [1 ]
Tsai, Meng-Tsan [3 ,4 ]
Liu, Linbo [1 ,2 ]
机构
[1] Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore 639798, Singapore
[2] Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore 637459, Singapore
[3] Chang Gung Univ, Dept Elect Engn, Taoyuan 33302, Taiwan
[4] Chang Gung Mem Hosp, Dept Dermatol, Linkou 33305, Taiwan
基金
中国国家自然科学基金; 新加坡国家研究基金会; 英国医学研究理事会;
关键词
IN-VIVO; SYNTHETIC-APERTURE; EXTENSION; MICROSCOPY; FILTERS; PROBE; BEAM;
D O I
10.1364/AO.57.006040
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We report a dual-focus fiber-optic probe designed to extend depth of focus (DOF) in high-resolution endoscopic optical coherence tomography. We exploited the broad spectral bandwidth of a supercontinuum source and, in the fiber probe, the foci of the 750-1000 nm and 1100-1450 nm inputs were axially chromatically shifted. The interference signals from the two spectral bands were measured with a Si camera-based spectrometer and an InGaAs camera-based spectrometer, respectively. We verified the feasibility of the design using a phantom composed of microparticles and swine small intestine tissue ex vivo. The results showed that a transverse resolution below 5 mu m over 300 mu m could be maintained, and that the extended DOF was 2 times larger than that of the single focus probe via the use of dual spectral band inputs and a chromatic focal shift. (C) 2018 Optical Society of America
引用
收藏
页码:6040 / 6046
页数:7
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