The role of T cells in age-related diseases

被引：117

作者：

Carrasco, Elisa ^{[1
,2
]}

Gomez de las Heras, Manuel M. ^{[2
,3
,4
]}

Gabande-Rodriguez, Enrique ^{[2
,3
,4
]}

Desdin-Mico, Gabriela ^{[2
,3
,4
]}

Francisco Aranda, Juan ^{[2
,3
,4
]}

Mittelbrunn, Maria ^{[2
,3
,4
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias UAM, Dept Biol, Madrid, Spain

[2] Univ Autonoma Madrid, Ctr Biol Mol Severe Ochoa CSIC UAM, Madrid, Spain

[3] Univ Autonoma Madrid, Fac Ciencias UAM, Dept Biol Mol, Madrid, Spain

[4] Inst Invest Sanitaria Hosp 12 Octubre I 12, Madrid, Spain

来源：

NATURE REVIEWS IMMUNOLOGY | 2022年 / 22卷 / 02期

基金：

欧盟地平线“2020”;

关键词：

DIET-INDUCED OBESITY; ABDOMINAL AORTIC-ANEURYSM; VISCERAL ADIPOSE-TISSUE; CENTRAL-NERVOUS-SYSTEM; INSULIN-RESISTANCE; GUT MICROBIOTA; IFN-GAMMA; ADAPTIVE IMMUNITY; INTERFERON-GAMMA; ATHEROSCLEROTIC PLAQUES;

D O I：

10.1038/s41577-021-00557-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this Review, Maria Mittelbrunn and colleagues highlight the involvement of T cells in diseases associated with ageing. In particular, the authors discuss how T cells contribute to inflammageing and the potential of targeting these populations for therapy of age-related diseases. Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue damage. In this Review, we discuss the role of T cells in the onset and progression of age-associated conditions, focusing on cardiovascular disorders, metabolic dysfunction, neuroinflammation and defective tissue repair and regeneration. We present different mechanisms by which T cells contribute to inflammageing and might act as modulators of age-associated diseases, including through enhanced pro-inflammatory and cytotoxic activity, defective clearance of senescent cells or regulation of the gut microbiota. Finally, we propose that 'resetting' immune system tolerance or targeting pathogenic T cells could open up new therapeutic opportunities to boost resilience to age-related diseases.

引用

页码：97 / 111

页数：15

共 194 条

[81] T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions [J].

Kipnis, J ;

Cohen, H ;

Cardon, M ;

Ziv, Y ;

Schwartz, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (21) :8180-8185

[82] γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis [J].

Kohlgruber, Ayano C. ;

Gal-Oz, Shani T. ;

LaMarche, Nelson M. ;

Shimazaki, Moto ;

Duquette, Danielle ;

Nguyen, Hung N. ;

Mina, Amir I. ;

Paras, Tyler ;

Tavakkoli, Ali ;

von Andrian, Ulrich ;

Banks, Alexander S. ;

Shay, Tal ;

Brenner, Michael B. ;

Lynch, Lydia .

NATURE IMMUNOLOGY, 2018, 19 (05) :464-+

[83] CD4+CD28null cells are an independent predictor of mortality in patients with heart failure [J].

Koller, Lorenz ;

Richter, Bernhard ;

Goliasch, Georg ;

Blum, Steffen ;

Korpak, Magdalena ;

Zorn, Gerlinde ;

Brekalo, Mira ;

Maurer, Gerald ;

Wojta, Johann ;

Pacher, Richard ;

Huelsmann, Martin ;

Niessner, Alexander .

ATHEROSCLEROSIS, 2013, 230 (02) :414-416

[84] Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice [J].

Kolodin, Dmitriy ;

van Panhuys, Nicolas ;

Li, Chaoran ;

Magnuson, Angela M. ;

Cipolletta, Daniela ;

Miller, Christine M. ;

Wagers, Amy ;

Germain, Ronald N. ;

Benoist, Christophe ;

Mathis, Diane .

CELL METABOLISM, 2015, 21 (04) :543-557

[85] Proteasome-Mediated Reduction in Proapoptotic Molecule Bim Renders CD4+CD28null T Cells Resistant to Apoptosis in Acute Coronary Syndrome [J].

Kovalcsik, Edit ;

Antunes, Ricardo F. ;

Baruah, Paramita ;

Kaski, Juan Carlos ;

Dumitriu, Ingrid E. .

CIRCULATION, 2015, 131 (08) :709-U94

[86] MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health [J].

Kubinak, Jason L. ;

Petersen, Charisse ;

Stephens, W. Zac ;

Soto, Ray ;

Bake, Erin ;

O'Connell, Ryan M. ;

Round, June L. .

CELL HOST & MICROBE, 2015, 17 (02) :153-163

[87] Intestinal alkaline phosphatase targets the gut barrier to prevent aging [J].

Kuehn, Florian ;

Adiliaghdam, Fatemeh ;

Cavallaro, Paul M. ;

Hamarneh, Sulaiman R. ;

Tsurumi, Amy ;

Hoda, Raza S. ;

Munoz, Alexander R. ;

Dhole, Yashoda ;

Ramirez, Juan M. ;

Liu, Enyu ;

Vasan, Robin ;

Liu, Yang ;

Samarbafzadeh, Ehsan ;

Nunez, Rocio A. ;

Farber, Matthew Z. ;

Chopra, Vanita ;

Malo, Madhu S. ;

Rahme, Laurence G. ;

Hodin, Richard A. .

JCI INSIGHT, 2020, 5 (06)

[88] IFN-γ-dependent activation of the brain's choroid plexus for CNS immune surveillance and repair [J].

Kunis, Gilad ;

Baruch, Kuti ;

Rosenzweig, Neta ;

Kertser, Alexander ;

Miller, Omer ;

Berkutzki, Tamara ;

Schwartz, Michal .

BRAIN, 2013, 136 :3427-3440

[89] Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells [J].

Kuswanto, Wilson ;

Burzyn, Dalia ;

Panduro, Marisella ;

Wang, Kathy K. ;

Jang, Young Charles ;

Wagers, Amy J. ;

Benoist, Christophe ;

Mathis, Diane .

IMMUNITY, 2016, 44 (02) :355-367

[90] Cytotoxic and Proinflammatory CD8+ T Lymphocytes Promote Development of Vulnerable Atherosclerotic Plaques in ApoE-Deficient Mice [J].

Kyaw, Tin ;

Winship, Amy ;

Tay, Christopher ;

Kanellakis, Peter ;

Hosseini, Hamid ;

Cao, Anh ;

Li, Priscilla ;

Tipping, Peter ;

Bobik, Alex ;

Toh, Ban-Hock .

CIRCULATION, 2013, 127 (09) :1028-+

← 4 5 6 7 8 9 10 11 12 13 →