The role of T cells in age-related diseases

被引：117

作者：

Carrasco, Elisa ^{[1
,2
]}

Gomez de las Heras, Manuel M. ^{[2
,3
,4
]}

Gabande-Rodriguez, Enrique ^{[2
,3
,4
]}

Desdin-Mico, Gabriela ^{[2
,3
,4
]}

Francisco Aranda, Juan ^{[2
,3
,4
]}

Mittelbrunn, Maria ^{[2
,3
,4
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias UAM, Dept Biol, Madrid, Spain

[2] Univ Autonoma Madrid, Ctr Biol Mol Severe Ochoa CSIC UAM, Madrid, Spain

[3] Univ Autonoma Madrid, Fac Ciencias UAM, Dept Biol Mol, Madrid, Spain

[4] Inst Invest Sanitaria Hosp 12 Octubre I 12, Madrid, Spain

来源：

NATURE REVIEWS IMMUNOLOGY | 2022年 / 22卷 / 02期

基金：

欧盟地平线“2020”;

关键词：

DIET-INDUCED OBESITY; ABDOMINAL AORTIC-ANEURYSM; VISCERAL ADIPOSE-TISSUE; CENTRAL-NERVOUS-SYSTEM; INSULIN-RESISTANCE; GUT MICROBIOTA; IFN-GAMMA; ADAPTIVE IMMUNITY; INTERFERON-GAMMA; ATHEROSCLEROTIC PLAQUES;

D O I：

10.1038/s41577-021-00557-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this Review, Maria Mittelbrunn and colleagues highlight the involvement of T cells in diseases associated with ageing. In particular, the authors discuss how T cells contribute to inflammageing and the potential of targeting these populations for therapy of age-related diseases. Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue damage. In this Review, we discuss the role of T cells in the onset and progression of age-associated conditions, focusing on cardiovascular disorders, metabolic dysfunction, neuroinflammation and defective tissue repair and regeneration. We present different mechanisms by which T cells contribute to inflammageing and might act as modulators of age-associated diseases, including through enhanced pro-inflammatory and cytotoxic activity, defective clearance of senescent cells or regulation of the gut microbiota. Finally, we propose that 'resetting' immune system tolerance or targeting pathogenic T cells could open up new therapeutic opportunities to boost resilience to age-related diseases.

引用

页码：97 / 111

页数：15

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