The role of T cells in age-related diseases

被引：117

作者：

Carrasco, Elisa ^{[1
,2
]}

Gomez de las Heras, Manuel M. ^{[2
,3
,4
]}

Gabande-Rodriguez, Enrique ^{[2
,3
,4
]}

Desdin-Mico, Gabriela ^{[2
,3
,4
]}

Francisco Aranda, Juan ^{[2
,3
,4
]}

Mittelbrunn, Maria ^{[2
,3
,4
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias UAM, Dept Biol, Madrid, Spain

[2] Univ Autonoma Madrid, Ctr Biol Mol Severe Ochoa CSIC UAM, Madrid, Spain

[3] Univ Autonoma Madrid, Fac Ciencias UAM, Dept Biol Mol, Madrid, Spain

[4] Inst Invest Sanitaria Hosp 12 Octubre I 12, Madrid, Spain

来源：

NATURE REVIEWS IMMUNOLOGY | 2022年 / 22卷 / 02期

基金：

欧盟地平线“2020”;

关键词：

DIET-INDUCED OBESITY; ABDOMINAL AORTIC-ANEURYSM; VISCERAL ADIPOSE-TISSUE; CENTRAL-NERVOUS-SYSTEM; INSULIN-RESISTANCE; GUT MICROBIOTA; IFN-GAMMA; ADAPTIVE IMMUNITY; INTERFERON-GAMMA; ATHEROSCLEROTIC PLAQUES;

D O I：

10.1038/s41577-021-00557-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this Review, Maria Mittelbrunn and colleagues highlight the involvement of T cells in diseases associated with ageing. In particular, the authors discuss how T cells contribute to inflammageing and the potential of targeting these populations for therapy of age-related diseases. Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue damage. In this Review, we discuss the role of T cells in the onset and progression of age-associated conditions, focusing on cardiovascular disorders, metabolic dysfunction, neuroinflammation and defective tissue repair and regeneration. We present different mechanisms by which T cells contribute to inflammageing and might act as modulators of age-associated diseases, including through enhanced pro-inflammatory and cytotoxic activity, defective clearance of senescent cells or regulation of the gut microbiota. Finally, we propose that 'resetting' immune system tolerance or targeting pathogenic T cells could open up new therapeutic opportunities to boost resilience to age-related diseases.

引用

页码：97 / 111

页数：15

共 194 条

[1] A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis [J].

Ahmadi, Shokouh ;

Wang, Shaohua ;

Nagpal, Ravinder ;

Wang, Bo ;

Jain, Shalini ;

Razazan, Atefeh ;

Mishra, Sidharth P. ;

Zhu, Xuewei ;

Wang, Zhan ;

Kavanagh, Kylie ;

Yadav, Hariom .

JCI INSIGHT, 2020, 5 (09)

[2] Natural regulatory T cells control the development of atherosclerosis in mice [J].

Ait-Oufella, H ;

Salomon, BL ;

Potteaux, S ;

Robertson, AKL ;

Gourdy, P ;

Zoll, J ;

Merval, R ;

Esposito, B ;

Cohen, JL ;

Fisson, S ;

Flavell, RA ;

Hansson, GK ;

Klatzmann, D ;

Tedgui, A ;

Mallat, Z .

NATURE MEDICINE, 2006, 12 (02) :178-180

[3] Are senescence and exhaustion intertwined or unrelated processes that compromise immunity? [J].

Akbar, Arne N. ;

Henson, Sian M. .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (04) :289-295

[4] Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation [J].

Ali, Niwa ;

Zirak, Bahar ;

Rodriguez, Robert Sanchez ;

Pauli, Mariela L. ;

Hong-An Truong ;

Lai, Kevin ;

Ahn, Richard ;

Corbin, Kaitlin ;

Lowe, Margaret M. ;

Scharschmidt, Tiffany C. ;

Taravati, Keyon ;

Tan, Madeleine R. ;

Ricardo-Gonzalez, Roberto R. ;

Nosbaum, Audrey ;

Bertolini, Marta ;

Liao, Wilson ;

Nestle, Frank O. ;

Paus, Ralf ;

Cotsarelis, George ;

Abbas, Abul K. ;

Rosenblum, Michael D. .

CELL, 2017, 169 (06) :1119-+

[5] Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons [J].

Alves de Lima, Kalil ;

Rustenhoven, Justin ;

Da Mesquita, Sandro ;

Wall, Morgan ;

Salvador, Andrea Francesca ;

Smirnov, Igor ;

Martelossi Cebinelli, Guilherme ;

Mamuladze, Tornike ;

Baker, Wendy ;

Papadopoulos, Zach ;

Lopes, Maria Beatriz ;

Cao, William Sam ;

Xie, Xinmin Simon ;

Herz, Jasmin ;

Kipnis, Jonathan .

NATURE IMMUNOLOGY, 2020, 21 (11) :1421-+

[6] Senolytic CAR T cells reverse senescence-associated pathologies [J].

Amor, Corina ;

Feucht, Judith ;

Leibold, Josef ;

Ho, Yu-Jui ;

Zhu, Changyu ;

Alonso-Curbelo, Direna ;

Mansilla-Soto, Jorge ;

Boyer, Jacob A. ;

Li, Xiang ;

Giavridis, Theodoros ;

Kulick, Amanda ;

Houlihan, Shauna ;

Peerschke, Ellinor ;

Friedman, Scott L. ;

Ponomarev, Vladimir ;

Piersigilli, Alessandra ;

Sadelain, Michel ;

Lowe, Scott W. .

NATURE, 2020, 583 (7814) :127-+

[7] Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells [J].

Ang, Qi Yan ;

Alexander, Margaret ;

Newman, John C. ;

Tian, Yuan ;

Cai, Jingwei ;

Upadhyay, Vaibhav ;

Turnbaugh, Jessie A. ;

Verdin, Eric ;

Hall, Kevin D. ;

Leibel, Rudolph L. ;

Ravussin, Eric ;

Rosenbaum, Michael ;

Patterson, Andrew D. ;

Turnbaugh, Peter J. .

CELL, 2020, 181 (06) :1263-+

[8] α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson's disease [J].

Arlehamn, Cecilia S. Lindestam ;

Dhanwani, Rekha ;

Pham, John ;

Kuan, Rebecca ;

Frazier, April ;

Dutra, Juliana Rezende ;

Phillips, Elizabeth ;

Mallal, Simon ;

Roederer, Mario ;

Marder, Karen S. ;

Amara, Amy W. ;

Standaert, David G. ;

Goldman, Jennifer G. ;

Litvan, Irene ;

Peters, Bjoern ;

Sulzer, David ;

Sette, Alessandro .

NATURE COMMUNICATIONS, 2020, 11 (01)

[9] A Distinct Function of Regulatory T Cells in Tissue Protection [J].

Arpaia, Nicholas ;

Green, Jesse A. ;

Moltedo, Bruno ;

Arvey, Aaron ;

Hemmers, Saskia ;

Yuan, Shaopeng ;

Treuting, Piper M. ;

Rudensky, Alexander Y. .

CELL, 2015, 162 (05) :1078-1089

[10] Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses [J].

Baixauli, Francesc ;

Acin-Perez, Rebeca ;

Villarroya-Beltri, Carolina ;

Mazzeo, Carla ;

Nunez-Andrade, Norman ;

Gabande-Rodriguez, Enrique ;

Dolores Ledesma, Maria ;

Blazquez, Alberto ;

Angel Martin, Miguel ;

Manuel Falcon-Perez, Juan ;

Miguel Redondo, Juan ;

Antonio Enriquez, Jose ;

Mittelbrunn, Maria .

CELL METABOLISM, 2015, 22 (03) :485-498

← 1 2 3 4 5 6 7 8 9 10 →