Hidden dynamics of vesicle adhesion induced by specific stickers

被引：58

作者：

Cuvelier, D ^{[1
]}

Nassoy, P ^{[1
]}

机构：

[1] PCC Inst Curie, CNRS, UMR 168, F-75005 Paris, France

来源：

PHYSICAL REVIEW LETTERS | 2004年 / 93卷 / 22期

关键词：

D O I：

10.1103/PhysRevLett.93.228101

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We experimentally studied the adhesion dynamics of vesicles decorated with specific stickers onto bioactive surfaces. The growth laws were found to strongly depend upon the chemical preparation of the substrate and were rationalized with theoretical descriptions based on scaling law arguments. By using a micropipette-free approach, we demonstrate that two-dimensional binding rates between receptor and ligand can be lower than three dimensional on rates by orders of magnitude due to reduced accessibility of the immobilized protein.

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页码：228101 / 1

页数：4

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