Cannabinoids for drug-resistant seizures in a critically ill patient-Case report and literature review

被引：0

作者：

Capra, Stefania ^{[1
]}

Narayan, Sujita W. ^{[2
]}

Parratt, Kaitlyn ^{[3
]}

Patanwala, Asad E. ^{[1
,2
]}

机构：

[1] Royal Prince Alfred Hosp, Dept Pharm, Camperdown, NSW, Australia

[2] Univ Sydney, Sch Pharm, Fac Med & Hlth, Sydney, NSW, Australia

[3] Royal Prince Alfred Hosp, Dept Neurol, Camperdown, NSW, Australia

来源：

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2020年 / 45卷 / 03期

关键词：

cannabidiol; cannabis; drug-resistant; epilepsy; neurology; seizures; EPILEPSY; CANNABIDIOL; MARIJUANA; COMPLEMENTARY;

D O I：

10.1111/jcpt.13082

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

What is known and objective Drug-resistant seizures are life-threatening and contribute to sustained hospitalization. We present the case of a critically ill 28-year-old male with Lennox-Gastaut syndrome who had approximately 30 seizures/day in the intensive care unit. Case description Patient required mechanical ventilation and pharmacologically induced thiopentone coma. He was commenced on cannabidiol and subsequently extubated. He remained seizure-free thereafter on a combination of cannabidiol and anti-epileptic medication that predated his critical illness. What is new and Conclusion Our case report provides a unique perspective on the role of cannabidiol in achieving remission from drug-resistant seizures in critically ill patients.

引用

页码：570 / 572

页数：3

共 26 条

[21] Evidence for cannabis and cannabinoids for epilepsy: a systematic review of controlled and observational evidence [J].

Stockings, Emily ;

Zagic, Dino ;

Campbell, Gabrielle ;

Weier, Megan ;

Hall, Wayne D. ;

Nielsen, Suzanne ;

Herkes, Geoffrey K. ;

Farrell, Michael ;

Degenhardt, Louisa .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2018, 89 (07) :741-753

[22] An Australian nationwide survey on medicinal cannabis use for epilepsy: History of antiepileptic drug treatment predicts medicinal cannabis use [J].

Suraev, Anastasia S. ;

Todd, Lisa ;

Bowen, Michael T. ;

Allsop, David J. ;

McGregor, Lain S. ;

Ireland, Carol ;

Lintzeris, Nicholas .

EPILEPSY & BEHAVIOR, 2017, 70 :334-340

[23] Cannabidiol improves frequency and severity of seizures and reduces adverse events in an open-label add-on prospective study [J].

Szaflarski, Jerzy P. ;

Bebin, Elizabeth Martina ;

Cutter, Gary ;

DeWolfe, Jennifer ;

Dure, Leon S. ;

Gaston, Tyler E. ;

Kankirawatana, Pongkiat ;

Liu, Yuliang ;

Singh, Rani ;

Standaert, David G. ;

Thomas, Ashley E. ;

Ver Hoef, Lawrence W. .

EPILEPSY & BEHAVIOR, 2018, 87 :131-136

[24] Long-term safety and treatment effects of cannabidiol in children and adults with treatment-resistant epilepsies: Expanded access program results [J].

Szaflarski, Jerzy P. ;

Bebin, Elizabeth Martina ;

Comi, Anne M. ;

Patel, Anup D. ;

Joshi, Charuta ;

Checketts, Daniel ;

Beal, Jules C. ;

Laux, Linda C. ;

De Boer, Lisa M. ;

Wong, Matthew H. ;

Lopez, Merrick ;

Devinsky, Orrin ;

Lyons, Paul D. ;

Zentil, Pilar Pichon ;

Wechsler, Robert .

EPILEPSIA, 2018, 59 (08) :1540-1548

[25] Cannabidiol in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study [J].

Thiele, Elizabeth ;

Marsh, Eric ;

Mazurkiewicz-Beldzinska, Maria ;

Halford, Jonathan J. ;

Gunning, Boudewijn ;

Devinsky, Orrin ;

Checketts, Daniel ;

Roberts, Claire .

EPILEPSIA, 2019, 60 (03) :419-428

[26] Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial [J].

Thiele, Elizabeth A. ;

Marsh, Eric D. ;

French, Jacqueline A. ;

Mazurkiewicz-Beldzinska, Maria ;

Benbadis, Selim R. ;

Joshi, Charuta ;

Lyons, Paul D. ;

Taylor, Adam ;

Roberts, Claire ;

Sommerville, Kenneth .

LANCET, 2018, 391 (10125) :1085-1096

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