Distribution of HPV types associated with cervical cancers in Scotland and implications for the impact of HPV vaccines

被引：18

作者：

Cuschieri, K. ^{[1
]}

Brewster, D. H. ^{[2
]}

Williams, A. R. W. ^{[3
]}

Millan, D. ^{[4
]}

Murray, G. ^{[5
]}

Nicoll, S. ^{[6
]}

Imrie, J. ^{[7
]}

Hardie, A. ^{[1
]}

Graham, C. ^{[8
]}

Cubie, H. A. ^{[1
]}

机构：

[1] Royal Infirm Edinburgh NHS Trust, Specialist Virol Ctr, Scottish HPV Reference Lab, Edinburgh EH16 4SA, Midlothian, Scotland

[2] NHS Natl Serv Scotland, Informat Serv Div, Scottish Canc Registry, Edinburgh EH12 9EB, Midlothian, Scotland

[3] Royal Infirm Edinburgh NHS Trust, Dept Pathol, Edinburgh EH16 4SA, Midlothian, Scotland

[4] Glasgow Royal Infirm, Dept Pathol, Glasgow G4 0SF, Lanark, Scotland

[5] Aberdeen Royal Infirm, Dept Pathol, Aberdeen AB25 2ZN, Scotland

[6] Ninewells Hosp, Dept Pathol, Dundee DD1 9SY, Scotland

[7] Monklands Gen Hosp, Dept Cytopathol, Airdrie ML6 OJS, Scotland

[8] Wellcome Trust Clin Res Facil, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

BRITISH JOURNAL OF CANCER | 2010年 / 102卷 / 05期

关键词：

HPV; genotyping; Scotland; LESIONS;

D O I：

10.1038/sj.bjc.6605556

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND/METHODS: This study evaluated human papillomavirus (HPV) type prevalence in 370 Scottish invasive cervical cancers (ICCs) using HPV genotyping and HPV mRNA detection. RESULTS: HPV 16 and/or 18 was detected in 72% of cancers overall and in 82% of HPV-positive cancers. HPV 45 and 16 were the most frequently transcribed types. CONCLUSION: A significant reduction in ICC in Scotland should be achieved through the HPV immunisation programme. British Journal of Cancer (2010) 102, 930-932. doi: 10.1038/sj.bjc.6605556 www.bjcancer.com Published online 9 February 2010 (C) 2010 Cancer Research UK

引用

页码：930 / 932

页数：3

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