Calcium signalling: Ringing changes to the 'bell-shaped curve'

被引：30
作者：
Bootman, MD [1 ]
Lipp, P [1 ]
机构：
[1] Babraham Inst, Mol Signalling Lab, Cambridge CB2 4AT, England
来源：
CURRENT BIOLOGY | 1999年 / 9卷 / 23期
关键词：
D O I：
10.1016/S0960-9822(00)80072-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The 'bell-shaped' curve relating cytosolic Ca2+ concentration to IP3 receptor activation is considered important in the generation of the complex Ca2+ signals seen inside many cells. But recent findings suggest this bimodal relationship is not always evident and may not apply to some IP3 receptor isoforms.
引用
收藏
页码：R876 / R878
页数：3
相关论文
共 10 条
  • [1] Lateral inhibition of inositol 1,4,5-trisphosphate receptors by cytosolic Ca2+
    Adkins, CE
    Taylor, CW
    [J]. CURRENT BIOLOGY, 1999, 9 (19) : 1115 - 1118
  • [2] Primer - Calcium signalling
    Berridge, M
    Lipp, P
    Bootman, M
    [J]. CURRENT BIOLOGY, 1999, 9 (05) : R157 - R159
  • [3] THE INOSITOL TRISPHOSPHATE CALCIUM-CHANNEL IS INACTIVATED BY INOSITOL TRISPHOSPHATE
    HAJNOCZKY, G
    THOMAS, AP
    [J]. NATURE, 1994, 370 (6489) : 474 - 477
  • [4] Inositol 1,4,5-tris-phosphate activation of inositol tris-phosphate receptor Ca2+ channel by ligand tuning of Ca2+ inhibition
    Mak, DOD
    McBride, S
    Foskett, JK
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) : 15821 - 15825
  • [5] Rapid activation and partial inactivation of inositol trisphosphate receptors by inositol trisphosphate
    Marchant, JS
    Taylor, CW
    [J]. BIOCHEMISTRY, 1998, 37 (33) : 11524 - 11533
  • [6] Calmodulin mediates calcium-dependent inactivation of the cerebellar type 1 inositol 1,14,5-trisphosphate receptor
    Michikawa, T
    Hirota, J
    Kawano, S
    Hiraoka, M
    Yamada, M
    Furuichi, T
    Mikoshiba, K
    [J]. NEURON, 1999, 23 (04) : 799 - 808
  • [7] MISSIAEN L, 1994, J BIOL CHEM, V269, P7238
  • [8] Encoding of Ca2+ signals by differential expression of IP3 receptor subtypes
    Miyakawa, T
    Maeda, A
    Yamazawa, T
    Hirose, K
    Kurosaki, T
    Iino, M
    [J]. EMBO JOURNAL, 1999, 18 (05) : 1303 - 1308
  • [9] Isoform-specific function of single inositol 1,4,5-trisphosphate receptor channels
    Ramos-Franco, J
    Fill, M
    Mignery, GA
    [J]. BIOPHYSICAL JOURNAL, 1998, 75 (02) : 834 - 839
  • [10] Inositol trisphosphate receptors:: Ca2+-modulated intracellular Ca2+ channels
    Taylor, CW
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1998, 1436 (1-2): : 19 - 33
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