Medicinal flowers.: XII.: New spirostane-type steroid Saponins with antidiabetogenic activity from Borassus flabellifer

被引：118

作者：

Yoshikawa, Masayuki

Xu, Fengming

Morikawa, Toshio

Pongpiriyadacha, Yutana

Nakamura, Seikou

Asao, Yasunobu

Kumahara, Akira

Matsuda, Hisashi

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

[2] Kinki Univ, Pharmaceut Res & Technol Inst, Higashiosaka, Osaka 5778502, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2007年 / 55卷 / 02期

关键词：

Borassus flabellifer; antidiabetogenic activity; borassoside; 22 beta-O-spirostane-type steroid saponin; dioscin;

D O I：

10.1248/cpb.55.308

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The methanolic extract from the male flowers of Borassus flabellifer was found to inhibit the increase of serum glucose levels in sucrose-loaded rats at a dose of 250 mg/kg, p.o. From the methanolic extract, six new spirostane-type steroid saponins, borassosides A-F (1-6), were isolated together with 23 known constituents. The structures of borassosides (1-6) were elucidated on the basis of chemical and physicochemical evidences. In addition, the principal steroid saponin, dioscin (13), inhibited the increase of serum glucose levels in sucroseloaded rats at a dose of 50 mg/kg, p.o.

引用

页码：308 / 316

页数：9

共 51 条

[1] 1'S-1'-acetoxychavicol acetate as a new type inhibitor of interferon-β production in lipopolysaccharide-activated mouse peritoneal macrophages [J].