Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging

被引：9

作者：

Stendahl, John C. ^{[1
]}

Kwan, Jennifer M. ^{[1
]}

Pucar, Darko ^{[2
]}

Sadeghi, Mehran M. ^{[1
,3
]}

机构：

[1] Yale Univ, Sch Med, Sect Cardiovasc Med, New Haven, CT 06520 USA

[2] Yale Univ, Dept Radiol & Biomed Imaging, Sch Med, New Haven, CT USA

[3] Vet Affairs Connecticut Healthcare Syst, West Haven, CT 06516 USA

来源：

JOURNAL OF NUCLEAR MEDICINE | 2022年 / 63卷 / 05期

关键词：

cardiology (basic/technical); cardiology (clinical); molecular imaging; inflammation; myocardial perfusion imaging; POSITRON-EMISSION-TOMOGRAPHY; IDIOPATHIC DILATED CARDIOMYOPATHY; CORONARY-ARTERY-DISEASE; MYOCARDIAL BLOOD-FLOW; SYMPATHETIC INNERVATION; HEART-FAILURE; IN-VIVO; C-11; HYDROXYEPHEDRINE; RECEPTOR DENSITY; DOWN-REGULATION;

D O I：

10.2967/jnumed.121.263506

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The development of new radiotracers for PET and SPECT is central to addressing unmet diagnostic needs related to systemwide trends toward molecular characterization and personalized therapies in cardiovascular medicine. In the following 2-part review, we discuss select emerging radiotracers that may help address important unmet diagnostic needs in central areas of cardiovascular medicine, such as heart failure, arrhythmias, valvular disease, atherosclerosis, and thrombosis. Part 1 examines key technical considerations pertaining to cardiovascular radiotracer development and reviews emerging radiotracers for perfusion and neuronal imaging. Highlights of this work include discussions on the development of F-18-flurpiridaz, an emerging PET perfusion tracer, and the development of F-18-based radiotracers for cardiovascular neuronal imaging, such as F-18-flubrobenguane. Part 2 of this review covers emerging radiotracers for the imaging of inflammation, fibrosis, thrombosis, calcification, and cardiac amyloidosis.

引用

页码：649 / 658

页数：10

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