Lymph nodes regression grade is a predictive marker for rectal cancer after neoadjuvant therapy and radical surgery

被引：8

作者：

Li, Jun ^{[1
]}

Yuan, Jiatian ^{[1
]}

Liu, Hao ^{[2
]}

Yin, Jie ^{[3
]}

Liu, Sai ^{[4
]}

Du, Feng ^{[5
,6
]}

Hu, Junjie ^{[7
]}

Li, Ci ^{[8
]}

Niu, Xiangke ^{[9
]}

Lv, Bo ^{[1
]}

Xing, Shasha ^{[10
]}

机构：

[1] Chengdu Univ, Clin Med Coll, Affiliated Hosp, Dept Gen Surg, Chengdu, Peoples R China

[2] Jilin Univ, Affiliated Hosp 2, Dept Gen Surg, Changchun 130023, Peoples R China

[3] Xuzhou Cent Hosp, Dept Gen Surg, Xuzhou, Peoples R China

[4] Capital Med Univ, Beijing Youan Hosp, Surg Dept Gastrointestinal Dis, Beijing, Peoples R China

[5] Peking Union Med Coll, Canc Inst Hosp, Internal Med Oncol, Beijing 100021, Peoples R China

[6] Chinese Acad Med Sci, Beijing 100730, Peoples R China

[7] Hubei Canc Hosp, Gastrointestinal Tumor Surg, Wuhan, Peoples R China

[8] Chengdu Univ, Clin Med Coll, Affiliated Hosp, Dept Pathol, Chengdu, Peoples R China

[9] Chengdu Univ, Clin Med Coll, Affiliated Hosp, Dept Radiol, Chengdu, Peoples R China

[10] Chengdu Univ, Clin Med Coll, Affiliated Hosp, Cent Lab, Chengdu, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 13期

关键词：

lymph node; regression grading; rectal cancer; neoadjuvant therapy; PATHOLOGICAL COMPLETE RESPONSE; WAIT-AND-SEE; TUMOR-REGRESSION; PREOPERATIVE CHEMORADIOTHERAPY; CHEMORADIATION; CARCINOMA;

D O I：

10.18632/oncotarget.7703

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neoadjuvant therapy (NT) for rectal cancer (RC) reduces primary tumors and involved lymph nodes. While a prognostic value of tumor regression grade (TRG) has been identified, involved lymph node regression grade (LRG) has not been systematically evaluated. Here, we evaluated the association of LRG with oncologic outcomes of RC patients after NT followed by radical surgery. 347 patients with locally advanced RC who received NT and then underwent radical surgery were retrospectively recruited between 2004 and 2011. Response to NT was evaluated by a 3-tier LRG and TRG based on the ratio of residual tumor to fibrosis. LRG was assessed in all patients (LRG 0, 170 patients [49.0%]; LRG 1, 100 patients [28.8%]; and LRG 2, 77 patients [22.2%]). LRG correlated with 5-year distant metastasis and 5-year disease free survival (p = 0.029 and 0.023, respectively). LRG also correlated with TRG (p = 0.017). We conclude that the LRG system may be an independent predictive factor of long-term oncologic outcomes of rectal cancer patients after NT and radical surgery.

引用

页码：16975 / 16984

页数：10

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