How to control miRNA maturation? Co-activators and co-repressors take the stage
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作者:
Trabucchi, Michele
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Univ Calif San Diego, Dept & Sch Med, Howard Hughes Med Inst, La Jolla, CA 92093 USAUniv Calif San Diego, Dept & Sch Med, Howard Hughes Med Inst, La Jolla, CA 92093 USA
Trabucchi, Michele
[1
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Briata, Paola
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Ist Nazl Ric Canc IST, Genoa, ItalyUniv Calif San Diego, Dept & Sch Med, Howard Hughes Med Inst, La Jolla, CA 92093 USA
Briata, Paola
[2
]
Filipowicz, Witold
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Friedrich Miescher Inst Biomed Res, Basel, SwitzerlandUniv Calif San Diego, Dept & Sch Med, Howard Hughes Med Inst, La Jolla, CA 92093 USA
Filipowicz, Witold
[3
]
Rosenfeld, Michael G.
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Univ Calif San Diego, Dept & Sch Med, Howard Hughes Med Inst, La Jolla, CA 92093 USAUniv Calif San Diego, Dept & Sch Med, Howard Hughes Med Inst, La Jolla, CA 92093 USA
Rosenfeld, Michael G.
[1
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Ramos, Andres
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Natl Inst Med Res, Ridgeway, Div Mol Struct, London NW7 1AA, EnglandUniv Calif San Diego, Dept & Sch Med, Howard Hughes Med Inst, La Jolla, CA 92093 USA
Ramos, Andres
[4
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Gherzi, Roberto
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Ist Nazl Ric Canc IST, Genoa, ItalyUniv Calif San Diego, Dept & Sch Med, Howard Hughes Med Inst, La Jolla, CA 92093 USA
Gherzi, Roberto
[2
]
机构:
[1] Univ Calif San Diego, Dept & Sch Med, Howard Hughes Med Inst, La Jolla, CA 92093 USA
[2] Ist Nazl Ric Canc IST, Genoa, Italy
[3] Friedrich Miescher Inst Biomed Res, Basel, Switzerland
[4] Natl Inst Med Res, Ridgeway, Div Mol Struct, London NW7 1AA, England
In this point of view we discuss the role of co-activators and co-repressors of miRNA precursors maturation, the possibility that their functions are post-translationally regulated by different signaling pathways, and their potential role in the miRNA-dependent control of cell proliferation and differentiation.