How to control miRNA maturation? Co-activators and co-repressors take the stage

被引:38
|
作者
Trabucchi, Michele [1 ]
Briata, Paola [2 ]
Filipowicz, Witold [3 ]
Rosenfeld, Michael G. [1 ]
Ramos, Andres [4 ]
Gherzi, Roberto [2 ]
机构
[1] Univ Calif San Diego, Dept & Sch Med, Howard Hughes Med Inst, La Jolla, CA 92093 USA
[2] Ist Nazl Ric Canc IST, Genoa, Italy
[3] Friedrich Miescher Inst Biomed Res, Basel, Switzerland
[4] Natl Inst Med Res, Ridgeway, Div Mol Struct, London NW7 1AA, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
KSRP; Lin-28; hnRNPA1; let-7; microRNA precursors; cell proliferation; RNA-BINDING PROTEIN; POSTTRANSCRIPTIONAL REGULATION; MICRORNA BIOGENESIS; NUCLEOCAPSID PROTEIN; HNRNP A1; KSRP; PROMOTES; LIN28; RECOGNITION; PHOSPHORYLATION;
D O I
10.4161/rna.6.5.10080
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this point of view we discuss the role of co-activators and co-repressors of miRNA precursors maturation, the possibility that their functions are post-translationally regulated by different signaling pathways, and their potential role in the miRNA-dependent control of cell proliferation and differentiation.
引用
收藏
页码:536 / 540
页数:5
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