Acute lymphoblastic leukemia presenting as acute hepatic failure in childhood

被引：24

作者：

Felice, MS ^{[1
]}

Hammermuller, E ^{[1
]}

De Dávila, MT ^{[1
]}

Ciocca, ME ^{[1
]}

Fraquelli, LE ^{[1
]}

Lorusso, AM ^{[1
]}

Sackmann-Muriel, F ^{[1
]}

机构：

[1] Hosp Pediat SAMIC Prof Dr Juan P Garrahan, Dept Hematol Oncol, RA-1245 Buenos Aires, DF, Argentina

来源：

LEUKEMIA & LYMPHOMA | 2000年 / 38卷 / 5-6期

关键词：

ALL; acute lymphoblastic leukemia; hepatic failure; presentation;

D O I：

10.3109/10428190009059284

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a 7-year/old white girl who was admitted because of acute severe hepatic failure. Her complete blood count revealed pancytopenia and a bone marrow aspiration was consistent with acute lymphoblastic leukemia (ALL). Blasts cells were positive for cytoplasmic CD3 and cell surface T-associated markers. Viral, metabolic, immune and toxic causes for hepatic failure were ruled out. Treatment pre-phase with prednisone was started and liver function tests clearly improved after one-week therapy. However, due to her hepatic insufficiency, daily etoposide was administered orally during 15 days. On day 33 complete remission was achieved and hepatic function was normal, except for an increase in the bilirubin level which normalized on day 72. She received our current treatment for intermediate risk ALL and is still receiving continuation phase therapy, currently, with normal liver function and good tolerance to chemotherapy + 8 months after achieving complete remission.

引用

页码：633 / 637

页数：5

共 13 条

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[2] Hepatitis B associated liver failure following bone marrow transplantation [J].