Importin α: functions as a nuclear transport factor and beyond

被引：95
作者：
Oka, Masahiro [1 ]
Yoneda, Yoshihiro [1 ]
机构：
[1] Natl Inst Biomed Innovat Hlth & Nutr NIBIOHN, 7-6-8 Saito Asagi, Ibaraki, Osaka 5670085, Japan
来源：
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 2018年 / 94卷 / 07期
关键词：
nuclear transport; nuclear localization signal; small GTPase Ran; nuclear pore-targeting complex; importin alpha; importin beta; PORE-TARGETING COMPLEX; YEAST SCHIZOSACCHAROMYCES-POMBE; LARGE T-ANTIGEN; PROTEIN IMPORT; LOCALIZATION SIGNAL; KARYOPHERIN-ALPHA; NUCLEOCYTOPLASMIC TRANSPORT; SYNTHETIC PEPTIDES; CELL-PROLIFERATION; LOCATION SEQUENCE;
D O I：
10.2183/pjab.94.018
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Nucleocytoplasmic transport is an essential process in eukaryotes. The molecular mechanisms underlying nuclear transport that involve the nuclear transport receptor, small GTPase Ran, and the nuclear pore complex are highly conserved from yeast to humans. On the other hand, it has become clear that the nuclear transport system diverged during evolution to achieve various physiological functions in multicellular eukaryotes. In this review, we first summarize the molecular mechanisms of nuclear transport and how these were elucidated. Then, we focus on the diverse functions of importin alpha, which acts not merely an import factor but also as a multi-functional protein contributing to a variety of cellular functions in higher eukaryotes.
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页码：259 / 274
页数：16
相关论文
共 127 条
[1]   IDENTIFICATION OF CYTOSOLIC FACTORS REQUIRED FOR NUCLEAR LOCATION SEQUENCE-MEDIATED BINDING TO THE NUCLEAR-ENVELOPE [J].
ADAM, EJH ;
ADAM, SA .
JOURNAL OF CELL BIOLOGY, 1994, 125 (03) :547-555
[2]   NUCLEAR-PROTEIN IMPORT IN PERMEABILIZED MAMMALIAN-CELLS REQUIRES SOLUBLE CYTOPLASMIC FACTORS [J].
ADAM, SA ;
MARR, RS ;
GERACE, L .
JOURNAL OF CELL BIOLOGY, 1990, 111 (03) :807-816
[3]   Regulation of nuclear lamin polymerization by importin α [J].
Adam, Stephen A. ;
Sengupta, Kaushik ;
Goldman, Robert D. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (13) :8462-8468
[4]   Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe [J].
Asakawa, Haruhiko ;
Yang, Hui-Ju ;
Yamamoto, Takaharu G. ;
Ohtsuki, Chizuru ;
Chikashige, Yuji ;
Sakata-Sogawa, Kumiko ;
Tokunaga, Makio ;
Iwamoto, Masaaki ;
Hiraoka, Yasushi ;
Haraguchi, Tokuko .
NUCLEUS, 2014, 5 (02) :149-162
[5]   Ran GTPase cycle and importins α and β are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos [J].
Askjaer, P ;
Galy, V ;
Hannak, E ;
Mattaj, IW .
MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (12) :4355-4370
[6]   ISOLATION OF A YEAST PROTEIN-KINASE THAT IS ACTIVATED BY THE PROTEIN ENCODED BY SRP1 (SRP1P) AND PHOSPHORYLATES SRP1P COMPLEXED WITH NUCLEAR-LOCALIZATION SIGNAL PEPTIDES [J].
AZUMA, Y ;
TABB, MM ;
VU, L ;
NOMURA, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) :5159-5163
[7]   Structural basis for the interaction between FxFG nucleoporin repeats and importin-β in nuclear trafficking [J].
Bayliss, R ;
Littlewood, T ;
Stewart, M .
CELL, 2000, 102 (01) :99-108
[8]   Axonal transcription factors signal retrogradely in lesioned peripheral nerve [J].
Ben-Yaakov, Keren ;
Dagan, Shachar Y. ;
Segal-Ruder, Yael ;
Shalem, Ophir ;
Vuppalanchi, Deepika ;
Willis, Dianna E. ;
Yudin, Dmitry ;
Rishal, Ida ;
Rother, Franziska ;
Bader, Michael ;
Blesch, Armin ;
Pilpel, Yitzhak ;
Twiss, Jeffery L. ;
Fainzilber, Mike .
EMBO JOURNAL, 2012, 31 (06) :1350-1363
[9]   CATALYSIS OF GUANINE-NUCLEOTIDE EXCHANGE ON RAN BY THE MITOTIC REGULATOR RCC1 [J].
BISCHOFF, FR ;
PONSTINGL, H .
NATURE, 1991, 354 (6348) :80-82
[10]   RANGAP1 INDUCED GTPASE ACTIVITY OF NUCLEAR RAS-RELATED RAN [J].
BISCHOFF, FR ;
KLEBE, C ;
KRETSCHMER, J ;
WITTINGHOFER, A ;
PONSTINGL, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (07) :2587-2591
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