Dearomatising rearrangements of lithiated thiophenecarboxamides

被引：22

作者：

Clayden, J

Turnbull, R

Helliwell, M

Pinto, I

机构：

[1] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

[2] GlaxoSmithKline Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 21期

关键词：

D O I：

10.1039/b409150g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Thiophene-3-carboxamides bearing allyl or benzyl substituents at nitrogen undergo dearomatising cyclisation on treatment with LDA. Rearrangements transform the dearomatised products into pyrrolinones, azepinones or partially saturated azepinothiophenes.

引用

收藏

页码：2430 / 2431

页数：2

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