Development of a Continuous-Flow Microreactor for Asymmetric Sulfoxidation Using a Biomimetic Manganese Catalyst

被引：18

作者：

Dai, Wen ^{[1
,2
]}

Mi, Yuan ^{[1
,2
]}

Lv, Ying ^{[1
,2
]}

Chen, Bo ^{[1
,2
]}

Li, Guosong ^{[1
,2
]}

Chen, Guangwen ^{[1
,2
]}

Gao, Shuang ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

[2] Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2016年 / 358卷 / 04期

关键词：

asymmetric sulfoxidation; biomimetic process; continuous flow conditions; microreactor; porphyrin-inspired catalyst; HYDROGEN-PEROXIDE; ENANTIOSELECTIVE SYNTHESIS; OXIDATION CATALYSIS; EPOXIDATION; SYSTEM; ORGANOCATALYSIS; SULFIDES; LIGANDS; COMPLEX; ALKENES;

D O I：

10.1002/adsc.201501023

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Asymmetric sulfoxidation catalyzed by a biomimetic manganese complex under continuous-flow microreactor is described. The reaction is conducted in microreactor, it can rapidly (<4min) oxidize a wide scope of sulfides with high yield (up to 91%) and excellent enantioselectivity (up to 99% ee), and allows shorter reaction times, easier scale-up and lower catalyst loadings than its batchwise counterpart. Additionally, a convenient numbering-up strategy for the scale-up of asymmetric sulfoxidation has been developed which enables a direct scaling of the reaction to 5g affording the corresponding sulfoxides within 20min.

引用

页码：667 / 671

页数：5

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