Association between Fok I vitamin D receptor gene (VDR) polymorphism and impulsivity in alcohol-dependent patients

被引:11
|
作者
Wrzosek, Malgorzata [1 ]
Jakubczyk, Andrzej [2 ]
Wrzosek, Michal [3 ]
Kaleta, Beata [4 ]
Lukaszkiewicz, Jacek [4 ]
Matsumoto, Halina [2 ]
Brower, Kirk [5 ]
Nowicka, Grazyna [1 ]
Wojnar, Marcin [2 ,5 ]
机构
[1] Med Univ Warsaw, Dept Pharmacogen, PL-02097 Warsaw, Poland
[2] Med Univ Warsaw, Dept Psychiat, PL-02097 Warsaw, Poland
[3] Med Univ Warsaw, Dept Internal Med & Diabetol, PL-02097 Warsaw, Poland
[4] Med Univ Warsaw, Dept Biochem & Clin Chem, PL-02097 Warsaw, Poland
[5] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA
关键词
Alcohol dependence; Impulsivity; Vitamin D receptor gene; Genetic polymorphism; D DEFICIENCY; ALTERS; RISK;
D O I
10.1007/s11033-014-3607-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Vitamin D appears to have an important role in the modulation of the central nervous system. Vitamin D exerts its biological effects through its interaction with the vitamin D receptor (VDR). Located on chromosome 12 (12q13.1), the VDR gene has many different polymorphisms. Some of them are known to affect the VDR function, such as FokI (rs2228570, T/C) single nucleotide polymorphism. We aimed to explore a potential relationship between FokI VDR polymorphism and impulsiveness in alcohol-dependent (AD) patients. The study population consisted of 148 patients diagnosed with alcohol dependence (DSM-IV criteria) and 212 healthy controls. DNA was extracted from whole blood samples using the standard procedure. Genotypes were analyzed using a real-time PCR method. We found that FokI VDR gene polymorphism was associated with impulsivity [Barratt Impulsiveness Scale (BIS)-11 total score; P = 0.014], and with attentional impulsivity (BIS-11 subscale; P = 0.002) in the male AD patients. Our results suggest that CC FokI genotype of the VDR gene is associated with a higher level of impulsivity in these patients. This finding supports the hypothesis that impulsiveness, which significantly contributes to development of alcohol dependence, has a genetic background.
引用
收藏
页码:7223 / 7228
页数:6
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