T-cell subsets: Transcriptional control in the Th1/Th2 decision

被引:56
作者
Rincon, M
Flavell, RA
机构
[1] UNIV VERMONT,DEPT MED,BURLINGTON,VT 05405
[2] YALE UNIV,SCH MED,HOWARD HUGHES MED INST,NEW HAVEN,CT 06520
关键词
D O I
10.1016/S0960-9822(06)00368-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Transcriptional mechanisms in CD4(+) T cells and antigen-presenting cells determine the activation or differentiation of Th1 and Th2 helper cell subsets, and also form attractive targets for therapeutic intervention in the balance of Th1/Th2 responses. (C) Current Biology Ltd ISSN 0960-9822.
引用
收藏
页码:R729 / R732
页数:4
相关论文
共 26 条
[21]   Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells [J].
Thierfelder, WE ;
vanDeursen, JM ;
Yamamoto, K ;
Tripp, RA ;
Sarawar, SR ;
Carson, RT ;
Sangster, MY ;
Vignali, DAA ;
Doherty, PC ;
Grosveld, GC ;
Ihle, JN .
NATURE, 1996, 382 (6587) :171-174
[22]   DISTINCT ROLES FOR THE COSTIMULATORY LIGANDS B7-1 AND B7-2 IN T-HELPER CELL-DIFFERENTIATION [J].
THOMPSON, CB .
CELL, 1995, 81 (07) :979-982
[23]   Interleukin-7 activates human naive CD4(+) cells and primes for interleukin-4 production [J].
Webb, LMC ;
Foxwell, BM ;
Feldmann, M .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (03) :633-640
[24]   An enhanced immune response in mice lacking the transcription factor NFAT1 [J].
Xanthoudakis, S ;
Viola, JPB ;
Shaw, KTY ;
Luo, C ;
Wallace, JD ;
Bozza, PT ;
Curran, T ;
Rao, A .
SCIENCE, 1996, 272 (5263) :892-895
[25]   Transcription factor GATA-3 is differentially expressed murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene [J].
Zhang, DH ;
Cohn, L ;
Ray, P ;
Bottomly, K ;
Ray, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (34) :21597-21603
[26]   The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells [J].
Zheng, WP ;
Flavell, RA .
CELL, 1997, 89 (04) :587-596