Electroacupuncture relieves neuropathic pain via upregulation of glutamate transporters in the spinal cord of rats

被引：28
作者：
Zeng, Jie [1 ]
Cui, Lu-ying [1 ]
Feng, Yan [1 ]
Ding, Ming-xing [1 ]
机构：
[1] Huazhong Agr Univ, Coll Vet Med, Wuhan 430070, Peoples R China
来源：
NEUROSCIENCE LETTERS | 2016年 / 620卷
基金：
中国国家自然科学基金;
关键词：
Neuropathic pain; Electroacupuncture; GLAST; GLT-1; l-trans-Pyrrolidine-2-4-dicarboxylate; NERVE INJURY; RECEPTOR ANTAGONISTS; GLIAL ACTIVATION; MODEL; TRANSMISSION; SUPPRESSION; PHYSIOLOGY;
D O I：
10.1016/j.neulet.2016.03.041
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Glutamate transports (GTs), the only vehicle for removal of glutamate from the extracellular fluid, is reported to be related to chronic pain. To investigate whether the glutamate/aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) participate in electroacupuncture (EA) analgesia, the EA effect was observed with paw withdraw threshold in a rat model of spared nerve injury. The expression levels of GLAST and GLT-1 were determined with Western Blot and RT-PCR. The results showed significantly upregulated GLAST and GLT-1, along with the relieved pain behaviors after EA treatment. In addition, intrathecal injection of GTs inhibitor, L-trans-pyrrolidine-2-4-dicarboxylate, attenuated the EA-induced analgesic effect. The experiment demonstrates that EA can increase the GTs of neuropathic pain rats, which might be one of the mechanisms underlying its effectiveness in the neuropathic pain. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：38 / 42
页数：5
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