Sinoatrial Arrest Caused by Ticagrelor after Angioplasty in a 62-Year-Old Woman with Acute Coronary Syndrome

被引：3

作者：

Ye, Fan ^{[1
,3
]}

Silverstein, Burton V. ^{[2
]}

Jansen, Michael ^{[2
]}

Bray, Christopher L. ^{[1
,3
]}

Lee, Arthur C. ^{[2
]}

机构：

[1] North Florida Reg Med Ctr, Dept Med & Grad Med Educ, Gainesville, FL 32605 USA

[2] North Florida Reg Med Ctr, Cardiac & Vasc Inst, Gainesville, FL 32605 USA

[3] Univ Cent Florida, Coll Med, Orlando, FL 32827 USA

来源：

TEXAS HEART INSTITUTE JOURNAL | 2019年 / 46卷 / 03期

关键词：

Acute coronary; syndrome/drug therapy; arrhythmias; cardiac/diagnosis/physiopathology; bradycardia/chemically induced; electrocardiography/drug effects; myocardial infarction/drug therapy; platelet aggregation inhibitors/adverse effects/therapeutic use; receptors; purinergic P2Y12; ticagrelor/adverse effects; treatment outcome; PLATO PLATELET INHIBITION; CLOPIDOGREL; BRADYARRHYTHMIAS; BRADYCARDIA; DIAGNOSIS;

D O I：

10.14503/THIJ-17-6554

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The platelet aggregation inhibitor ticagrelor, a P2Y(12) receptor antagonist, is widely used after angioplasty in patients with acute coronary syndrome. Clinical trial data have shown that it is well tolerated by most patients. We present the case of a 62-year-old woman whose ticagrelor-related asymptomatic and persistent sinus pauses after angioplasty resolved when ticagrelor was replaced with prasugrel.

引用

页码：203 / 206

页数：4

共 14 条

[1]

Amsterdam EA, 2014, J AM COLL CARDIOL, V64, P2713, DOI [10.1016/j.jacc.2014.09.016, 10.1016/j.jacc.2014.09.017, 10.1016/j.jacc.2014.10.011, 10.1161/CIR.0000000000000134]

[2] Ticagrelor Increases Adenosine Plasma Concentration in Patients With an Acute Coronary Syndrome [J].

Bonello, Laurent ;

Laine, Marc ;

Kipson, Nathalie ;

Mancini, Julien ;

Helal, Olfa ;

Fromonot, Julien ;

Gariboldi, Vlad ;

Condo, Jocelyne ;

Thuny, Franck ;

Frere, Corinne ;

Camoin-Jau, Laurence ;

Paganelli, Franck ;

Dignat-George, Francoise ;

Guieu, Regis .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 63 (09) :872-877

[3] ARRHYTHMIAS DOCUMENTED BY 24-HOUR CONTINUOUS ELECTROCARDIOGRAPHIC MONITORING IN 50 MALE MEDICAL-STUDENTS WITHOUT APPARENT HEART-DISEASE [J].

BRODSKY, M ;

WU, D ;

DENES, P ;

KANAKIS, C ;

ROSEN, KM .

AMERICAN JOURNAL OF CARDIOLOGY, 1977, 39 (03) :390-395

[4] Diagnosis, pathophysiology, and management of exercise-induced arrhythmias [J].

Guasch, Eduard ;

Mont, Lluis .

NATURE REVIEWS CARDIOLOGY, 2017, 14 (02) :88-101

[5] SIGNIFICANCE OF VENTRICULAR PAUSES OF 3 SECONDS OR MORE DETECTED ON 24-HOUR HOLTER RECORDINGS [J].

HILGARD, J ;

EZRI, MD ;

DENES, P .

AMERICAN JOURNAL OF CARDIOLOGY, 1985, 55 (08) :1005-1008

[6] The Incidence of Bradyarrhythmias and Clinical Bradyarrhythmic Events in Patients With Acute Coronary Syndromes Treated With Ticagrelor or Clopidogrel in the PLATO (Platelet Inhibition and Patient Outcomes) Trial Results of the Continuous Electrocardiographic Assessment Substudy [J].

Scirica, Benjamin M. ;

Cannon, Christopher P. ;

Emanuelsson, Hakan ;

Michelson, Eric L. ;

Harrington, Robert A. ;

Husted, Steen ;

James, Stefan ;

Katus, Hugo ;

Pais, Prem ;

Raev, Dimitar ;

Spinar, Jindrich ;

Steg, Ph. Gabriel ;

Storey, Robert F. ;

Wallentin, Lars .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 57 (19) :1908-1916

[7]

Semelka M, 2013, AM FAM PHYSICIAN, V87, P691

[8] NORMAL SINUS HEART-RATE - SINUS TACHYCARDIA AND SINUS BRADYCARDIA REDEFINED [J].

SPODICK, DH .

AMERICAN HEART JOURNAL, 1992, 124 (04) :1119-1121

[9] Inhibition of platelet aggregation by AZD6140, A reversible oral P2Y12 receptor antagonist, compared with clopidogral in patients with acute coronary syndrome [J].

Storey, Robert F. ;

Husted, Steen ;

Harrington, Robert A. ;

Heptinstall, Stanley ;

Wilcox, Robert G. ;

Peters, Gary ;

Wickens, Mark ;

Emanuelsson, Hakan ;

Gurbel, Paul ;

Grande, Peer ;

Cannon, Christopher P. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (19) :1852-1856

[10] Inhibitory Effects of Ticagrelor Compared With Clopidogrel on Platelet Function in Patients With Acute Coronary Syndromes The PLATO (PLATelet inhibition and patient Outcomes) PLATELET Substudy [J].

Storey, Robert F. ;

Angiolillo, Dominick J. ;

Patil, Shankar B. ;

Desai, Bhaloo ;

Ecob, Rosemary ;

Husted, Steen ;

Emanuelsson, Hakan ;

Cannon, Christopher P. ;

Becker, Richard C. ;

Wallentin, Lars .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (18) :1456-1462

← 1 2 →