Synthesis, Characterization, and Antimicrobial Activity of a Series of 2-(5-Phenyl-1,3,4-oxadiazol-2-yl)-N-[(1-aryl-1H-1,2,3-triazol-4-yl)methyl]anilines Using Click Chemistry

被引：8

作者：

Venkatagiri, N. ^{[1
]}

Krishna, T. ^{[1
]}

Thirupathi, P. ^{[2
]}

Bhavani, K. ^{[1
]}

Reddy, C. K. ^{[1
]}

机构：

[1] Osmania Univ, Dept Chem, Hyderabad 500007, Telangana, India

[2] Loyola Acad Degree & PG Coll, Dept Chem, Secunderabad 500010, Telangana, India

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2018年 / 88卷 / 07期

关键词：

triazolyloxadiazoles; 1; 2; 3-triazole; 3; 4-oxadiazole; click reaction; microorganisms; antibacterial activity; antifungal activity; BIOLOGICAL EVALUATION; ACID; DERIVATIVES; 1,2,3-TRIAZOLES; AGENTS;

D O I：

10.1134/S1070363218070228

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of new triazolyl derived 1,3,4-oxadiazoles 7a-7l is synthesized with high yields by coppercatalyzed alkyne-azide cycloaddition reaction between a variety of substituted aryl/alkyl azides and 2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline. Structures of intermediates and the final compounds are confirmed by FTIR, H-1 and C-13 NMR, and Mass spectra. The synthesized compounds demonstrate moderate antibacterial activity and potent antifungal activity against the tested strains.

引用

页码：1488 / 1494

页数：7

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