Effects of Carnosine Supplementation on Glucose Metabolism: Pilot Clinical Trial

被引:124
作者
de Courten, Barbora [1 ,2 ]
Jakubova, Michaela [3 ,4 ]
de Courten, Maximilian P. J. [5 ]
Kukurova, Ivica Just [6 ,7 ]
Vallova, Silvia [3 ,4 ]
Krumpolec, Patrik [3 ]
Valkovic, Ladislav [6 ,7 ]
Kurdiova, Timea [3 ]
Garzon, Davide [8 ]
Barbaresi, Silvia [9 ]
Teede, Helena J. [1 ,2 ]
Derave, Wim [9 ]
Krssak, Martin [6 ,7 ,10 ]
Aldini, Giancarlo [8 ]
Ukropec, Jozef [3 ]
Ukropcova, Barbara [3 ,4 ]
机构
[1] Monash Ctr Hlth Res & Implementat, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia
[2] Monash Hlth, Diabet & Vasc Med Unit, Clayton, Vic, Australia
[3] Slovak Acad Sci, Inst Expt Endocrinol, Bratislava, Slovakia
[4] Comenius Univ, Fac Med, Bratislava, Slovakia
[5] Victoria Univ, Coll Hlth & Biomed, Ctr Chron Dis, Melbourne, Vic 8001, Australia
[6] Med Univ Vienna, High Field MR Ctr, Dept Biomed Imaging & Image Guided Therapy, Vienna, Austria
[7] Christian Doppler Lab Clin Mol MR Imaging, Vienna, Austria
[8] Univ Milan, Dept Pharmaceut Sci, Milan, Italy
[9] Univ Ghent, Dept Movement & Sport Sci, B-9000 Ghent, Belgium
[10] Med Univ Vienna, Dept Internal Med 3, Div Endocrinol & Metab, Vienna, Austria
基金
奥地利科学基金会; 英国医学研究理事会;
关键词
INSULIN-RESISTANCE; LIFETIME RISK; DOUBLE-BLIND; DETOXIFICATION; HISTIDINE; DISEASE; TYPE-2; RATS; INDIVIDUALS; GLYCATION;
D O I
10.1002/oby.21434
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Carnosine is a naturally present dipeptide in humans and an over-the counter food additive. Evidence from animal studies supports the role for carnosine in the prevention and treatment of diabetes and cardiovascular disease, yet there is limited human data. This study investigated whether carnosine supplementation in individuals with overweight or obesity improves diabetes and cardiovascular risk factors. Methods: In a double-blind randomized pilot trial in nondiabetic individuals with overweight and obesity (age 43 +/- 8 years; body mass index 31 +/- 4 kg/m(2)), 15 individuals were randomly assigned to 2 g carnosine daily and 15 individuals to placebo for 12 weeks. Insulin sensitivity and secretion, glucose tolerance (oral glucose tolerance test), blood pressure, plasma lipid profile, skeletal muscle (H-1-MRS), and urinary carnosine levels were measured. Results: Carnosine concentrations increased in urine after supplementation (P<0.05). An increase in fasting insulin and insulin resistance was hampered in individuals receiving carnosine compared to placebo, and this remained significant after adjustment for age, sex, and change in body weight (P=0.02, P=0.04, respectively). Two-hour glucose and insulin were both lower after carnosine supplementation compared to placebo in individuals with impaired glucose tolerance (P<0.05). Conclusions: These pilot intervention data suggest that carnosine supplementation may be an effective strategy for prevention of type 2 diabetes.
引用
收藏
页码:1027 / 1034
页数:8
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