Cardiovascular Involvement in Autoimmune Diseases

被引:58
作者
Amaya-Amaya, Jenny [1 ,2 ]
Montoya-Sanchez, Laura [1 ,2 ]
Rojas-Villarraga, Adriana [1 ,2 ]
机构
[1] Univ Rosario, Sch Med & Hlth Sci, Ctr Autoimmune Dis Res CREA, Bogota 11001000, Colombia
[2] Hosp Univ Mayor, Bogota 11001000, Colombia
关键词
SYSTEMIC-LUPUS-ERYTHEMATOSUS; PRIMARY SJOGRENS-SYNDROME; CORONARY-ARTERY-DISEASE; INTIMA-MEDIA THICKNESS; RHEUMATOID-ARTHRITIS PATIENTS; C-REACTIVE PROTEIN; LOW-DENSITY-LIPOPROTEIN; US COHORT LUMINA; ANKYLOSING-SPONDYLITIS PATIENTS; ENDOTHELIAL-CELL ACTIVATION;
D O I
10.1155/2014/367359
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Autoimmune diseases (AD) represent a broad spectrum of chronic conditions that may afflict specific target organs or multiple systems with a significant burden on quality of life. These conditions have common mechanisms including genetic and epigenetics factors, gender disparity, environmental triggers, pathophysiological abnormalities, and certain subphenotypes. Atherosclerosis (AT) was once considered to be a degenerative disease that was an inevitable consequence of aging. However, research in the last three decades has shown that AT is not degenerative or inevitable. It is an autoimmune-inflammatory disease associated with infectious and inflammatory factors characterized by lipoprotein metabolism alteration that leads to immune system activation with the consequent proliferation of smooth muscle cells, narrowing arteries, and atheroma formation. Both humoral and cellular immune mechanisms have been proposed to participate in the onset and progression of AT. Several risk factors, known as classic risk factors, have been described. Interestingly, the excessive cardiovascular events observed in patients with ADs are not fully explained by these factors. Several novel risk factors contribute to the development of premature vascular damage. In this review, we discuss our current understanding of how traditional and nontraditional risk factors contribute to pathogenesis of CVD in AD.
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页数:31
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