Astaxanthin supplementation attenuates immobilization-induced skeletal muscle fibrosis via suppression of oxidative stress

被引：33

作者：

Maezawa, Toshiyuki ^{[1
]}

Tanaka, Masayuki ^{[1
,2
]}

Kanazashi, Miho ^{[3
]}

Maeshige, Noriaki ^{[1
]}

Kondo, Hiroyo ^{[4
]}

Ishihara, Akihiko ^{[5
]}

Fujino, Hidemi ^{[1
]}

机构：

[1] Kobe Univ, Dept Rehabil Sci, Grad Sch Hlth Sci, Suma Ku, 7-10-2 Tomogaoka, Kobe, Hyogo 6540142, Japan

[2] Osaka Univ Human Sci, Dept Phys Therapy, Fac Human Sci, 1-4-1 Shojaku, Settsu, Osaka 5668501, Japan

[3] Prefectural Univ Hiroshima, Dept Phys Therapy, Fac Hlth & Welf, 1-1 Gakuen Cho, Mihara, Hiroshima 7230053, Japan

[4] Nagoya Womens Univ, Dept Food Sci & Nutr, Mizuho Ku, 4-21 Shioji Cho, Nagoya, Aichi 4678611, Japan

[5] Kyoto Univ, Lab Cell Biol & Life Sci, Grad Sch Human & Environm Studies, Sakyo Ku, Yoshida Nihonmatsu Cho, Kyoto, Kyoto 6068501, Japan

来源：

JOURNAL OF PHYSIOLOGICAL SCIENCES | 2017年 / 67卷 / 05期

基金：

日本学术振兴会;

关键词：

Skeletal muscle fibrosis; Transforming growth factor-beta 1; Reactive oxygen species; Astaxanthin; Immobilization; REACTIVE OXYGEN; PULMONARY-FIBROSIS; SOLEUS MUSCLE; TGF-BETA; CAPILLARY REGRESSION; COLLAGEN PRODUCTION; LIPID-METABOLISM; LUNG FIBROSIS; UP-REGULATION; HUMAN HEALTH;

D O I：

10.1007/s12576-016-0492-x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Immobilization induces skeletal muscle fibrosis characterized by increasing collagen synthesis in the perimysium and endomysium. Transforming growth factor-beta 1 (TGF-beta 1) is associated with this lesion via promoting differentiation of fibroblasts into myofibroblasts. In addition, reactive oxygen species (ROS) are shown to mediate TGF-beta 1-induced fibrosis in tissues. These reports suggest the importance of ROS reduction for attenuating skeletal muscle fibrosis. Astaxanthin, a powerful antioxidant, has been shown to reduce ROS production in disused muscle. Therefore, we investigated the effects of astaxanthin supplementation on muscle fibrosis under immobilization. In the present study, immobilization increased the collagen fiber area, the expression levels of TGF-beta 1, alpha-smooth muscle actin, and superoxide dismutase-1 protein and ROS production. However, these changes induced by immobilization were attenuated by astaxanthin supplementation. These results indicate the effectiveness of astaxanthin supplementation on skeletal muscle fibrosis induced by ankle joint immobilization.

引用

页码：603 / 611

页数：9

共 58 条

[1] Astaxanthin modulates osteopontin and transforming growth factor β1 expression levels in a rat model of nephrolithiasis: a comparison with citrate administration [J].