Family-based association study for bipolar affective disorder

被引：9
|
作者：
Secolin, Rodrigo
Banzato, Claudio E. M. [2 ]
Oliveira, Maria C. M. [2 ]
Bittar, Maria F. R.
Santos, Marilza L.
Dalgalarrondo, Paulo [2 ]
Lopes-Cendes, Iscia [1 ]
机构：
[1] Univ Estadual Campinas, FCM, Dept Med Genet, BR-13084971 Campinas, SP, Brazil
[2] Univ Estadual Campinas, Dept Med Psychol & Psychiat, BR-13084971 Campinas, SP, Brazil
来源：
PSYCHIATRIC GENETICS | 2010年 / 20卷 / 03期
基金：
巴西圣保罗研究基金会;
关键词：
genetics; mood disorders; pedigree disequilibrium test; single nucleotide polymorphisms; GENOME-WIDE ASSOCIATION; GENETICS; SUSCEPTIBILITY; METAANALYSIS; SUPPORTS; LOCI;
D O I：
10.1097/YPG.0b013e32833a2050
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In this study we aimed to evaluate 21 candidate loci for bipolar affective disorder (BPAD) identified earlier in a large genome-wide association study. We evaluated 74 pedigrees with BPAD, with a total of 411 individuals, including 96 patients who fulfilled clinical criteria for BPAD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition classification. Family-based association analysis was performed using the UNPHASED software. We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P-corrected=0.0025) with an odds ratio = 2.64 (95% confidence interval: 1.30-5.35). Single nucleotide polymorphism rs9834970 is located in an intergenic region and is not known to be associated to regulatory genomic sequences. Psychiatr Genet 20:126-129 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码：126 / 129
页数：4
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