Modulation of the effects of chylomicron remnants on endothelial function by minor dietary lipid components

被引:14
|
作者
Perona, J. S. [1 ]
Cabello-Moruno, R. [1 ]
Ruiz-Gutierrez, V. [1 ]
机构
[1] CSIC, Inst Grasa, Seville 41012, Spain
关键词
adhesion molecule; chylomicron remnant; cytokine; endothelial dysfunction; phytosterol; tocopherol; VIRGIN OLIVE OIL; LOW-DENSITY-LIPOPROTEIN; RECEPTOR-RELATED PROTEIN; CELL-ADHESION; ALPHA-TOCOPHEROL; PLANT STEROLS; MEDITERRANEAN DIET; URSOLIC ACID; RISK-FACTORS; OLEIC-ACID;
D O I
10.1042/BST0350446
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
There is emerging evidence that minor components from dietary oils can modulate or even improve events occurring in the development of atherosclerosis. one of the earliest events of the atherosclerotic process is endothelial dysfunction, which is an activation of the endothelium manifested by an increase in proinflammatory molecules, such as cytokines and adhesion molecules. Chylomicron remnants, such as LDL (low-density lipoprotein), are considered to be pro-atherogenic lipoproteins because they interact with endothelial cells and macrophages, increasing endothelial dysfunction mainly by the disturbance of the redox state in the cell.However, chylomicrons are, at the same time, the natural carriers of dietary lipids in plasma, which gives minor lipid components the opportunity to interact with the cells implicated in endothelial dysfunction and atherogenesis. Some of these components are known to exhibit antioxiclant, anti-inflammatory and anti-atherogenic effects in vitro, even forming part of triacylglycerol-rich lipoproteins, such as chylomicrons.
引用
收藏
页码:446 / 450
页数:5
相关论文
共 50 条
  • [1] Effects of chylomicron remnants on endothelial function in rat aorta
    Grieve, DJ
    Avella, MA
    Botham, KM
    Elliott, J
    BRITISH JOURNAL OF PHARMACOLOGY, 1997, 120 : P157 - P157
  • [2] Influence of Lipid Content and Oxidation State of Chylomicron Remnants on Endothelial Cell Signalling And Function
    Dalla-Riva, J.
    Garonna, E.
    Elliott, J.
    Botham, K. M.
    Wheeler-Jones, C. P. D.
    ATHEROSCLEROSIS SUPPLEMENTS, 2010, 11 (01) : 82 - 82
  • [3] The uptake of chylomicron remnants and their effects on endothelial cell function in the perfused rat aorta
    Grieve, DJ
    Avella, MA
    Elliott, J
    Botham, KM
    ATHEROSCLEROSIS, 1997, 134 (1-2) : 344 - 345
  • [4] Effects of oxidised chylomicron remnants on endothelial cell function in the perfused and freshly isolated rat aorta
    Grieve, DJ
    Avella, MA
    Elliott, J
    Botham, KM
    BRITISH JOURNAL OF PHARMACOLOGY, 1998, 123 : U169 - U169
  • [5] The influence of chylomicron remnants on endothelial cell function in the isolated perfused rat aorta
    Grieve, DJ
    Avella, MA
    Elliott, J
    Botham, KM
    ATHEROSCLEROSIS, 1998, 139 (02) : 273 - 281
  • [6] Differential effects of low-density lipoprotein and chylomicron remnants on lipid accumulation in human macrophages
    Batt, KV
    Avella, M
    Moore, EH
    Jackson, B
    Suckling, KE
    Botham, KM
    EXPERIMENTAL BIOLOGY AND MEDICINE, 2004, 229 (06) : 528 - 537
  • [7] MODULATION OF LIPID-PEROXIDATION BY DIETARY-COMPONENTS
    SUJATHA, R
    SRINIVAS, L
    TOXICOLOGY IN VITRO, 1995, 9 (03) : 231 - 236
  • [8] Dietary modulation of human endothelial function by homocysteine
    Usui, M
    Matsuoka, H
    Miyazaki, H
    Ueda, S
    Fujisawa, M
    Okuda, S
    Imaizumi, T
    JOURNAL OF HYPERTENSION, 1998, 16 : S87 - S87
  • [9] Chylomicron components mediate intestinal lipid-induced inhibition of gastric motor function
    Glatzle, J
    Kalogeris, TJ
    Zittel, TT
    Guerrini, S
    Tso, P
    Raybould, HE
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2002, 282 (01): : G86 - G91
  • [10] Dietary modulation of endothelial function: implications for cardiovascular disease
    Brown, AA
    Hu, FB
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 2001, 73 (04): : 673 - 686