Combining Three Cohorts of World Trade Center Rescue/Recovery Workers for Assessing Cancer Incidence and Mortality

被引:14
作者
Brackbill, Robert M. [1 ]
Kahn, Amy R. [2 ]
Li, Jiehui [1 ]
Zeig-Owens, Rachel [3 ,4 ,5 ]
Goldfarb, David G. [3 ,4 ]
Skerker, Molly [3 ,4 ,5 ]
Farfel, Mark R. [1 ]
Cone, James E. [1 ]
Yung, Janette [1 ]
Walker, Deborah J. [1 ]
Solomon, Adrienne [1 ]
Qiao, Baozhen [2 ]
Schymura, Maria J. [2 ]
Dasaro, Christopher R. [6 ]
Kristjansson, Dana [7 ]
Webber, Mayris P. [3 ,4 ,5 ]
Lucchini, Roberto G. [6 ]
Todd, Andrew C. [6 ]
Prezant, David J. [3 ,4 ,5 ]
Boffetta, Paolo [8 ,9 ]
Hall, Charles B. [5 ]
机构
[1] New York City Dept Hlth & Mental Hyg, World Trade Ctr Hlth Registry, Long Isl City, NY 11101 USA
[2] New York State Dept Hlth, Bur Canc Epidemiol, Albany, NY 12237 USA
[3] Fire Dept City New York FDNY, Brooklyn, NY 11201 USA
[4] Montefiore Med Ctr, Dept Med, New York, NY 10467 USA
[5] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA
[6] Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA
[7] Norwegian Inst Publ Hlth, Dept Genet & Bioinformat, N-0456 Oslo, Norway
[8] SUNY Stony Brook, Stony Brook Canc Ctr, Stony Brook, NY 11794 USA
[9] Univ Bologna, Dept Med & Surg Sci, I-40138 Bologna, Italy
基金
美国国家卫生研究院;
关键词
World Trade Center; exposure; cancer; rescue and recovery workers; pooling cohorts; YORK-CITY FIREFIGHTERS; CENTER RESPONDERS; POOLED COHORT; SAN-FRANCISCO; HEALTH; EXPOSURE; OUTCOMES; ATTACKS; CHICAGO;
D O I
10.3390/ijerph18041386
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Three cohorts including the Fire Department of the City of New York (FDNY), the World Trade Center Health Registry (WTCHR), and the General Responder Cohort (GRC), each funded by the World Trade Center Health Program have reported associations between WTC-exposures and cancer. Results have generally been consistent with effect estimates for excess incidence for all cancers ranging from 6 to 14% above background rates. Pooling would increase sample size and de-duplicate cases between the cohorts. However, pooling required time consuming steps: obtaining Institutional Review Board (IRB) approvals and legal agreements from entities involved; establishing an honest broker for managing the data; de-duplicating the pooled cohort files; applying to State Cancer Registries (SCRs) for matched cancer cases; and finalizing analysis data files. Obtaining SCR data use agreements ranged from 6.5 to 114.5 weeks with six states requiring >20 weeks. Records from FDNY (n = 16,221), WTCHR (n = 29,372), and GRC (n = 33,427) were combined de-duplicated resulting in 69,102 unique individuals. Overall, 7894 cancer tumors were matched to the pooled cohort, increasing the number cancers by as much as 58% compared to previous analyses. Pooling resulted in a coherent resource for future research for studies on rare cancers and mortality, with more representative of occupations and WTC- exposure.
引用
收藏
页码:1 / 17
页数:17
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