Synthesis and biological evaluation of nitric oxide-releasing matrine derivatives as anticancer agents

被引：21
|
作者：
He, Li Qin [1 ,2 ]
Liu, Jing [2 ]
Yin, Deng Ke [2 ]
Zhang, Yi Hua [1 ]
Wang, Xiao Shan [2 ]
机构：
[1] China Pharmaceut Univ, Ctr Drug Discovery, Nanjing 210009, Peoples R China
[2] Anhui Univ Tradit Chinese Med, Anhui Key Lab Modernized Chinese Mat Med, Hefei 230031, Anhui, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 04期
关键词：
Matrine; Furoxan; Anti-tumor activity; HepG2; DONORS; APOPTOSIS;
D O I：
10.1016/j.cclet.2009.11.033
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of furoxan-based nitric oxide-releasing matrine derivatives (10a-f) were synthesized. The biological evaluation showed that compounds 10a, 10b, 10e and 10f had stronger cytotoxic activities than 5-fluorouracil against human hepatoma cells (HepG2) in vitro. (C) 2009 Yi Hua Zhang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：381 / 384
页数：4
相关论文
共 50 条
  • [1] Synthesis and biological evaluation of nitric oxide-releasing matrine derivatives as anticancer agents
    Li Qin He~(a
    ChineseChemicalLetters, 2010, 21 (04) : 381 - 384
  • [2] Synthesis and biological evaluation of nitric oxide-releasing sixalkoxyl biphenyl derivatives as anticancer agents
    Xiang Wen Kong a
    Chinese Chemical Letters, 2008, (02) : 149 - 152
  • [3] Synthesis and biological evaluation of nitric oxide-releasing sixalkoxyl biphenyl derivatives as anticancer agents
    Kong, Xiang Wen
    Zhang, Yi Hua
    Dai, Li
    Ji, Hui
    Lai, Yi Sheng
    Peng, Si Xun
    CHINESE CHEMICAL LETTERS, 2008, 19 (02) : 149 - 152
  • [4] Novel nitric oxide-releasing derivatives of pyranocarbazole as antitumor agents: Design, synthesis, biological evaluation, and nitric oxide release studies
    Zang, Yingda
    Huang, Lei
    Chen, Xinyi
    Li, Chuangjun
    Ma, Jie
    Chen, Xiaguang
    Lai, Fangfang
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 244
  • [5] Design, synthesis and biological evaluation of matrine derivatives as potential anticancer agents
    Li, Zheng
    Luo, Mengyang
    Cai, Bin
    Wu, Lichuan
    Huang, Mengtian
    Haroon-Ur-Rashid
    Jiang, Jun
    Wang, Lisheng
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (04) : 677 - 683
  • [6] Synthesis and Bioactivity of Furoxan-Based Nitric Oxide-Releasing Colchicine Derivatives as Anticancer Agents
    Shen, Li Hong
    Wang, Sheng Li
    Li, Hong Yu
    Lai, Yi Sheng
    Liu, Li Jie
    ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (06) : 3294 - 3296
  • [7] Nitric oxide-releasing derivatives of brefeldin A as potent and highly selective anticancer agents
    Tian, Kangtao
    Xu, Fanxing
    Gao, Xiang
    Han, Tong
    Li, Jia
    Pan, Huaqi
    Zang, Linghe
    Li, Dahong
    Li, Zhanlin
    Uchita, Takahiro
    Gao, Ming
    Hua, Huiming
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 136 : 131 - 143
  • [8] Synthesis and Biological Evaluation of the Matrine Derivatives as a Novel Family of Potential Anticancer Agents
    Wang, Jing
    Liu, Hang
    Zhuo, Xiao-Bin
    Ye, Guang-Ming
    Zhao, Qing-Jie
    MEDICINAL CHEMISTRY, 2021, 17 (05) : 493 - 500
  • [9] Novel Nitric Oxide-Releasing Derivatives of Brusatol as Anti-Inflammatory Agents: Design, Synthesis, Biological Evaluation, and Nitric Oxide Release Studies
    Tang, Weibin
    Xie, Jianlin
    Xu, Song
    Lv, Haining
    Lin, Mingbao
    Yuan, Shaopeng
    Bai, Jinye
    Hou, Qi
    Yu, Shishan
    JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (18) : 7600 - 7612
  • [10] Synthesis, biological evaluation and mechanism studies of matrine derivatives as anticancer agents
    Jiang, Lihe
    Wu, Lichuan
    Yang, Fangfang
    Almosnid, Nadin
    Liu, Xu
    Jiang, Jun
    Altman, Elliot
    Wang, Lisheng
    Gao, Ying
    ONCOLOGY LETTERS, 2017, 14 (03) : 3057 - 3064
12345