共 50 条
Synthesis and biological evaluation of nitric oxide-releasing matrine derivatives as anticancer agents
被引:21
|作者:
He, Li Qin
[1
,2
]
Liu, Jing
[2
]
Yin, Deng Ke
[2
]
Zhang, Yi Hua
[1
]
Wang, Xiao Shan
[2
]
机构:
[1] China Pharmaceut Univ, Ctr Drug Discovery, Nanjing 210009, Peoples R China
[2] Anhui Univ Tradit Chinese Med, Anhui Key Lab Modernized Chinese Mat Med, Hefei 230031, Anhui, Peoples R China
关键词:
Matrine;
Furoxan;
Anti-tumor activity;
HepG2;
DONORS;
APOPTOSIS;
D O I:
10.1016/j.cclet.2009.11.033
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
A series of furoxan-based nitric oxide-releasing matrine derivatives (10a-f) were synthesized. The biological evaluation showed that compounds 10a, 10b, 10e and 10f had stronger cytotoxic activities than 5-fluorouracil against human hepatoma cells (HepG2) in vitro. (C) 2009 Yi Hua Zhang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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页码:381 / 384
页数:4
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