The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

被引：95

作者：

Bandapalli, Obul R. ^{[1
,2
]}

Schuessele, Stephanie ^{[1
,2
]}

Kunz, Joachim B. ^{[1
,2
]}

Rausch, Tobias ^{[3
]}

Stutz, Adrian M. ^{[3
]}

Tal, Noa

Geron, Ifat ^{[4
,5
,6
,7
,8
]}

Gershman, Nava ^{[4
,5
,6
]}

Izraeli, Shai ^{[4
,5
,6
]}

Eilers, Juliane ^{[1
,2
]}

Vaezipour, Nina ^{[2
]}

Kirschner-Schwabe, Renate ^{[9
]}

Hof, Jana ^{[9
,10
]}

von Stackelberg, Arend ^{[9
]}

Schrappe, Martin ^{[11
]}

Stanulla, Martin ^{[11
,12
]}

Zimmermann, Martin ^{[12
]}

Koehler, Rolf ^{[13
]}

Avigad, Smadar ^{[14
]}

Handgretinger, Rupert ^{[15
]}

Frismantas, Viktoras ^{[16
]}

Bourquin, Jean Pierre ^{[16
]}

Bornhauser, Beat ^{[16
]}

Korbel, Jan O. ^{[3
]}

Muckenthaler, Martina U. ^{[1
,2
]}

Kulozik, Andreas E. ^{[1
,2
]}

机构：

[1] Heidelberg Univ, Childrens Hosp, Dept Pediat Oncol Hematol & Immunol, D-69115 Heidelberg, Germany

[2] Heidelberg Univ, EMBL, Mol Med Partnership Unit, D-69115 Heidelberg, Germany

[3] EMBL, Genome Biol Unit, Heidelberg, Germany

[4] Sheba Med Ctr, Childhood Leukemia Res Inst, Tel Hashomer, Israel

[5] Sheba Med Ctr, Dept Pediat Hemato Oncol, Tel Hashomer, Israel

[6] Tel Aviv Univ, IL-69978 Tel Aviv, Israel

[7] Univ Calif San Diego, Div Biol Sci, San Diego, CA 92103 USA

[8] Univ Calif San Diego, Dept Med Stem Cell Program, San Diego, CA 92103 USA

[9] Charit Univ Med Berlin, Dept Pediat Oncol Hematol, Berlin, Germany

[10] German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany

[11] Univ Hosp Schleswig Holstein, Campus Kiel, Germany

[12] Hannover Med Sch, Dept Pediat Hematol Oncol, Hannover, Germany

[13] Heidelberg Univ, Dept Human Genet, D-69115 Heidelberg, Germany

[14] Schneider Childrens Med Ctr Israel, Felsenstein Med Res Ctr & Pediat Hematol Oncol, Petah Tiqwa, Israel

[15] Univ Tubingen Hosp, Childrens Hosp, Tubingen, Germany

[16] Univ Childrens Hosp Zurich, Dept Oncol, Zurich, Switzerland

来源：

HAEMATOLOGICA | 2014年 / 99卷 / 10期

关键词：

STAT5B; mutation; pediatric T-ALL; OF-FUNCTION MUTATIONS; CONSTITUTIVE ACTIVATION; IL7R;

D O I：

10.3324/haematol.2014.104992

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：E188 / E192

页数：5

共 15 条

[1] Constitutive activation of STAT5 by a point mutation in the SH2 domain
Ariyoshi, K
Nosaka, T
Yamada, K
Onishi, M
Oka, Y
Miyajima, A
Kitamura, T
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (32) : 24407 - 24413
[2] Comprehensive Analysis of Transcriptome Variation Uncovers Known and Novel Driver Events in T-Cell Acute Lymphoblastic Leukemia
Atak, Zeynep Kalender
Gianfelici, Valentina
Hulselmans, Gert
De Keersmaecker, Kim
Devasia, Arun George
Geerdens, Ellen
Mentens, Nicole
Chiaretti, Sabina
Durinck, Kaat
Uyttebroeck, Anne
Vandenberghe, Peter
Wlodarska, Iwona
Cloos, Jacqueline
Foa, Robin
Speleman, Frank
Cools, Jan
Aerts, Stein
[J]. PLOS GENETICS, 2013, 9 (12):
[3] NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia
Bandapalli, Obul R.
Zimmermann, Martin
Kox, Corinne
Stanulla, Martin
Schrappe, Martin
Ludwig, Wolf-Dieter
Koehler, Rolf
Muckenthaler, Martina U.
Kulozik, Andreas E.
[J]. HAEMATOLOGICA, 2013, 98 (06) : 928 - 936
[4] Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia
Breit, Stephen
Stanulla, Martin
Flohr, Thomas
Schrappe, Martin
Ludwig, Wolf-Dieter
Tolle, Gabriele
Happich, Margit
Muckenthaler, Martina U.
Kulozik, Andreas E.
[J]. BLOOD, 2006, 108 (04) : 1151 - 1157
[5] Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia
De Keersmaecker, Kim
Atak, Zeynep Kalender
Li, Ning
Vicente, Carmen
Patchett, Stephanie
Girardi, Tiziana
Gianfelici, Valentina
Geerdens, Ellen
Clappier, Emmanuelle
Porcu, Michael
Lahortiga, Idoya
Luca, Rossella
Yan, Jiekun
Hulselmans, Gert
Vranckx, Hilde
Vandepoel, Roel
Sweron, Bram
Jacobs, Kris
Mentens, Nicole
Wlodarska, Iwona
Cauwelier, Barbara
Cloos, Jacqueline
Soulier, Jean
Uyttebroeck, Anne
Bagni, Claudia
Hassan, Bassem A.
Vandenberghe, Peter
Johnson, Arlen W.
Aerts, Stein
Cools, Jan
[J]. NATURE GENETICS, 2013, 45 (02) : 186 - 190
[6] Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia
Flex, Elisabetta
Petrangeli, Valentina
Stella, Lorenzo
Chiaretti, Sabina
Hornakova, Tekla
Knoops, Laurent
Ariola, Cristina
Fodale, Valentina
Clappier, Emmanuelle
Paoloni, Francesca
Martinelli, Simone
Fragale, Alessandra
Sanchez, Massimo
Tavolaro, Simona
Messina, Monica
Cazzaniga, Giovanni
Camera, Andrea
Pizzolo, Giovanni
Tornesello, Assunta
Vignetti, Marco
Battistini, Angela
Cave, Helene
Gelb, Bruce D.
Renauld, Jean-Christophe
Biondi, Andrea
Constantinescu, Stefan N.
Foa, Robin
Tartaglia, Marco
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (04) : 751 - 758
[7] Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B
Hennighausen, Lothar
Robinson, Gertraud W.
[J]. GENES & DEVELOPMENT, 2008, 22 (06) : 711 - 721
[8] Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia
Kleppe, Maria
Lahortiga, Idoya
El Chaar, Tiama
De Keersmaecker, Kim
Mentens, Nicole
Graux, Carlos
Van Roosbroeck, Katrien
Ferrando, Adolfo A.
Langerak, Anton W.
Meijerink, Jules P. P.
Sigaux, Francois
Haferlach, Torsten
Wlodarska, Iwona
Vandenberghe, Peter
Soulier, Jean
Cools, Jan
[J]. NATURE GENETICS, 2010, 42 (06) : 530 - U84
[9] Kontro M, 2014, LEUKEMIA
[10] The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL-BFM 2000 protocol can be separated from FBXW7 loss of function
Kox, C.
Zimmermann, M.
Stanulla, M.
Leible, S.
Schrappe, M.
Ludwig, W-D
Koehler, R.
Tolle, G.
Bandapalli, O. R.
Breit, S.
Muckenthaler, M. U.
Kulozik, A. E.
[J]. LEUKEMIA, 2010, 24 (12) : 2005 - 2013

← 1 2 →